LUMS-SSE Biology Research Seminar Series - 2012
The Department of Biology at SSE- LUMS brings a seminar on
Epigenetic cell memory and Cell Signaling
Dr. Saima Anwar, Lecturer
Supervisor: Dr. Muhammad. Tariq
Date: Monday, May 7, 2012
Time: 01:00 p.m. – 02:00 p.m.
Venue: Smart Lab, CS
About the Seminar
During course of development of multicellular organisms, cells become committed to a particular fate by changing their genetic programme in response to the transient stimuli. Signal transduction pathways are responsible for the orchestration of most of these signals into specific transcriptional states by the modulation of chromatin structure that activates or represses transcription at particular loci. However, when these transient stimuli are no more there, “cellular memory” enable cells to remember their chosen fate over many rounds of cell division. Two antagonistic groups of proteins, Polycomb and Trithorax, work to maintain repressed or active states of developmentally regulated genes respectively. But epigenetic states are irreversible and change in response to the appropriate signals but how cell memory players respond to these signals is still a mystery. A deeper understanding of how polycomb group proteins respond to these external stimuli will allow us to tackle the dysregulation of epigenetic in disease and normal development.
Our research interests include development of a Reporter system for genome wide profiling of all cell memory players which will be helpful to resolve some of the unresolved mysteries. In parallel we are also trying to identify that how two members of polycomb group proteins, Polycomb (PC), a PRC1 component and Enhancer of Zetse E(Z), a PRC2 component are behaving in the dynamic regulation of cell memory.