Biology Talk on Transcription Initiation at LUMS- SSE
Abbas Raza, the Research Assistant at Department of Biology, School of Science and Engineering (SSE), LUMS delivered a talk titled; "Probing Determinants of Transcription Initiation in Sulfolobus Solfataricus" on May 21, 2012.
The seminar was about the existence of a separate transcription initiation pathway in archaea which involved no transcription accessory factors like TFB/TBP. That had led to the specualation about the direct binding of RNAP to initiator sequences within the genome. Session talked about what kinds of INR sequences were more accessible to DNA-protein interaction and the identification of those sub-units of RNAP, which actually had the affinity towards DNA in initiating that pathway.
It was explained by Raza, how this study would lead to a much better understanding of the mechanism by which RNAP-INR interactions take place and how that impact promoter strength.
The seminar concluded with a question-answer session, which was well- entertained by Raza.