Department of Biology presents a talk on
Screening of novel compounds that target the interaction of LC3 and FUNDC1 for inhibition of Auto(mito)phagy
Guest Speaker: Dr. Arslan Sehgal
Date: Wednesday, October 30, 2019
Time: 11:00-12:00 noon
Venue: SBASSE Smart Lab, Dean’s Office
Host: Dr. Aziz Mithani
The mitophagy is a key process that removes damaged and unwanted mitochondria, thus determining the quality and homeostasis of the mitochondria within a cell. Four novel compounds disturb the binding interactions of LC3 and FUNDC1. All of these compounds also showed the potential to inhibit the auto(mito)phagy. It was also observed that all the compounds inhibit autophagy and helps in the transformation of LC3-I into LC3-II leads to the accumulation of LC3-II. In conclusion, the compounds NAI003, NAI010, NAI037 and NAI038 showed inhibition of auto(mito)phagy flux.
Dr. Arslan Sehgal did his BS and MS in Bioinformatics and PhD in Cell Biology with a specialisation in Bioinformatics. He has published numerous International articles of computational drug designing and also published an international book on computational drug designing.