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Email: aziz.mithani@lums.edu.pk
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Dr. Aziz Mithani

Assistant Professor

Department Of Biology

Dr Aziz Mithani started as a computer scientist and received his Masters in Computer Sciences from FAST-NU, Karachi before going to University of Cambridge, UK where he did MPhil in Computational Biology. In summer 2006, he went to Harvard Medical School for a research internship in Paulsson Lab at Department of Systems Biology. Dr Mithani received his DPhil inStatistics (Computational Biology) from University of Oxford, UK in November 2009 under the supervision of Prof Jotun Hein and Dr Gail Preston. His dissertation focused on modelling the evolution and analysis of the properties of metabolic networks. Subsequently, Dr Mithani joined Harberd Lab at the Department of Plant Sciences, University of Oxford, UK as a postdoctoral research associate where he worked for two years on the evolution of bread wheat. 

His research interests include the application of computational and mathematical methods in the area of modern biology. Specifically, he is interested in the development of computational tools and techniques to model and analyse biological systems, and to investigate how different organisms evolve over time.

TitlePublicationAuthorYear
DNA mismatch repair preferentially protects genes from mutationGenome ResearchBelfield E.J., Ding Z.J., Jamieson F.J.C., Visscher A.M., Zheng S.J., Mithani A., Harberd N.P.2018
HANDS2: Accurate assignment of homoeallelic base-identity in allopolyploids despite missing dataScientific ReportsKhan A., Belfield E.J., Harberd N.P., Mithani A.2016
Local adaptation is associated with zinc tolerance in Pseudomonas endophytes of the metal-hyperaccumulator plant Noccaea caerulescensProceedings of the Royal Society B: Biological SciencesFones H.N., McCurrach H., Mithani A., Smith J.A.C., Preston G.M.2016
Patterns of homoeologous gene expression shown by RNA sequencing in hexaploid bread wheatBMC GenomicsLeach L.J., Belfield E.J., Jiang C., Brown C., Mithani A., Harberd N.P.2014
Microarray-based ultra-high resolution discovery of genomic deletion mutationsBMC GenomicsBelfield E.J., Brown C., Gan X., Jiang C., Baban D., Mithani A., Mott R., Ragoussis J., Harberd N.P.2014
Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutationsGenome ResearchJiang C., Mithani A., Belfield E.J., Mott R., Hurst L.D., Harberd N.P.2014
Microarray-based optimization to detect genomic deletion mutationsGenomics DataBelfield E.J., Brown C., Gan X., Jiang C., Baban D., Mithani A., Mott R., Ragoussis J., Harberd N.P.2014
HANDS: A tool for genome-wide discovery of subgenome-specific base-identity in polyploidsBMC GenomicsMithani A., Belfield E.J., Brown C., Jiang C., Leach L.J., Harberd N.P.2013
Erratum: ROS-mediated vascular homeostatic control of root-to-shoot soil Na delivery in Arabidopsis (EMBO Journal (2012) 31 (4359-4370) DOI: 10.1038/emboj.2012.273)EMBO JournalJiang C., Belfield E.J., Mithani A., Visscher A., Ragoussis J., Mott R., Andrew Smith J., Harberd N.P.2013
ROS-mediated vascular homeostatic control of root-to-shoot soil Na delivery in ArabidopsisEMBO JournalJiang C., Belfield E.J., Mithani A., Visscher A., Ragoussis J., Mott R., Smith J.A.C., Harberd N.P.2012
Genome-wide analysis of mutations in mutant lineages selected following fast-neutron irradiation mutagenesis of Arabidopsis thalianaGenome ResearchBelfield E.J., Gan X., Mithani A., Brown C., Jiang C., Franklin K., Alvey E., Wibowo A., Jung M., Bailey K., Kalwani S., Ragoussis J., Mott R., Harberd N.P.2012
Regenerant arabidopsis lineages display a distinct genome-wide spectrum of mutations conferring variant phenotypesCurrent BiologyJiang C., Mithani A., Gan X., Belfield E.J., Klingler J.P., Zhu J.-K., Ragoussis J., Mott R., Harberd N.P.2011
Comparative analysis of metabolic networks provides insight into the evolution of plant pathogenic and nonpathogenic lifestyles in PseudomonasMolecular Biology and EvolutionMithani A., Hein J., Preston G.M.2011
A Bayesian approach to the evolution of metabolic networks on a phylogenyPLoS Computational BiologyMithani A., Preston G.M., Hein J.2010
Rahnuma: Hypergraph-based tool for metabolic pathway prediction and network comparisonBioinformaticsMithani A., Preston G.M., Hein J.2009
A stochastic model for the evolution of metabolic networks with neighbor dependenceBioinformaticsMithani A., Preston G.M., Hein J.2009
SemesterTitleCode
Spring Semester 2017-18Master's Thesis1702
Spring Semester 2017-18Senior Project1702
Spring Semester 2017-18Computational Genomics1702
Spring Semester 2017-18Genome Informatics1702
Spring Semester 2017-18Topics in Systems Biology1702
Spring Semester 2017-18Doctoral Thesis Research1702
Spring Semester 2017-18Doctoral Thesis Research1702
Spring Semester 2017-18Systems Biology1702
Spring Semester 2017-18Computational Biology I1702
Spring Semester 2017-18Biology Laboratory1702
Fall Semester 2017-18Master's Thesis1701
Fall Semester 2017-18Senior Project1701
Fall Semester 2017-18Doctoral Thesis Research1701
Fall Semester 2017-18Doctoral Thesis Research1701
Fall Semester 2017-18Advanced Methods in Biology1701
Fall Semester 2017-18Genetics1701
Fall Semester 2017-18Computational Biology II1701
Fall Semester 2017-18Methods in Cell and Molecular Biology1701
Summer Semester 2016-17Doctoral Thesis Research1603
Spring Semester 2016-17Topics in Systems Biology1602
Spring Semester 2016-17Doctoral Thesis Research1602
Spring Semester 2016-17Doctoral Thesis Research1602
Spring Semester 2016-17Genetics and Genomics1602
Spring Semester 2016-17Systems Biology1602
Spring Semester 2016-17Computational Biology I1602
Spring Semester 2016-17Biology Laboratory1602
Spring Semester 2016-17Introductory Biology1602
Fall Semester 2016-17Doctoral Thesis Research1601
Fall Semester 2016-17Advanced Methods in Biology1601
Fall Semester 2016-17Genetics1601
Fall Semester 2016-17Computational Biology II1601
Fall Semester 2016-17Methods in Cell and Molecular Biology1601
Summer Semester 2015-16Doctoral Thesis Research1503
Spring Semester 2015-16Topics in Systems Biology1502
Spring Semester 2015-16Doctoral Thesis Research1502
Spring Semester 2015-16Master's Thesis II1502
Spring Semester 2015-16Genetics and Genomics1502
Spring Semester 2015-16Computational Biology I1502
Spring Semester 2015-16Biology Laboratory1502
Spring Semester 2015-16Introductory Biology1502
Fall Semester 2015-16Doctoral Thesis Research1501
Fall Semester 2015-16Master's Thesis I1501
Fall Semester 2015-16Advanced Methods in Biology1501
Fall Semester 2015-16Computational Biology II1501
Fall Semester 2015-16Methods in Cell and Molecular Biology1501
Fall Semester 2015-16Introductory Biology1501
Spring Semester 2014-15Genetics and Genomics1402
Spring Semester 2014-15Advance Biochemistry1402
Spring Semester 2014-15Biological Networks1402
Spring Semester 2014-15Network Biology1402
Spring Semester 2014-15Developmental Biology 11402
Spring Semester 2014-15Computational Biology I1402
Spring Semester 2014-15Biology Laboratory1402
Spring Semester 2014-15Senior Project II1402
Spring Semester 2014-15Introductory Biology1402
Fall Semester 2014-15Genetics and Genomics1401
Fall Semester 2014-15Advanced Methods in Biology1401
Fall Semester 2014-15Genetics1401
Fall Semester 2014-15Computational Biology II1401
Fall Semester 2014-15Senior Project II1401
Fall Semester 2014-15Senior Project I1401
Fall Semester 2014-15Methods in Cell and Molecular Biology1401
  • Past Courses
    SemesterTitleCode
    Spring Semester 2013-14Systems Biology1302
    Spring Semester 2013-14Computational Biology1302
    Spring Semester 2013-14Biology Laboratory1302
    Spring Semester 2013-14Senior Project I1302
    Spring Semester 2013-14Introductory Biology1302
    Fall Semester 2013-14Advanced Methods in Biology1301
    Fall Semester 2013-14Computational Biology II1301
    Fall Semester 2013-14Senior Project II1301
    Fall Semester 2013-14Methods in Cell and Molecular Biology1301
    Spring Semester 2012-13Biological Networks1202
    Spring Semester 2012-13Network Biology1202
    Spring Semester 2012-13Computational Biology I1202
    Spring Semester 2012-13Senior Project II1202
    Spring Semester 2012-13Seminar in Biology-II1202
    Spring Semester 2012-13Introductory Biology1202
    Spring Semester 2012-13Senior Project II1202
    Fall Semester 2012-13Computational Biology II1201
    Fall Semester 2012-13Senior Project I1201
    Fall Semester 2012-13Seminars in Biology1201
    Fall Semester 2012-13Senior Project I1201
    Spring Semester 2011-12Gene Regulation and Epigenetics1102
    Spring Semester 2011-12Introduction to Computational Biology and Bioinformatics1102
    Spring Semester 2011-12Senior Project I1102
    Spring Semester 2011-12Independent Study1102
    Spring Semester 2011-12Introductory Biology1102