Faculty Profile

Dr. Syed Shahzad ul Hussan

Associate Professor

Department Of Biology

Dr Shahzad ul Hussan joined the Department of Biology at SSE in December 2013 as an Associate Professor. He did his Ph. D. in Bioorganic Chemistry from the University of Luebeck, Germany in 2005. In 2005, he obtained the Postdoctoral Fellowship Award from the National Institutes of Health (NIH), USA and joined the Laboratory of Bioorganic Chemistry at NIDDK, NIH.  During the postdoctoral training his research was focused on NMR structural studies of anti-HIV lectins and understanding the sub-molecular level basis of HIV entry inhibition by those lectins. In 2010, Dr Hussan Joined the Vaccine Research Center of NIAID at NIH as a research fellow where the focus of his research was to study the atomic level details of HIV-surface-displayed-glycan recognition by HIV-1 neutralizing antibodies. His research during last 10 years has resulted in several publications in high-ranking journals namely, Nature, Science, Nature Structural and Molecular Biology, Journal of the American Chemical Society, Journal of Biological Chemistry, Chembiochem and Journal of Virology. His research interests, in general, include understanding the structural properties of ligands in their macromolecular-bound state, the solution structure of proteins and biophysical characterization of recognition phenomenon involving glycans. He has implemented his expertise in understanding the atomic level details of recognition involving viruses. Further details about his current research at his rearch group page at http://biolabs.lums.edu.pk/BSB

Evolution of efficacious pangenotypic hepatitis C virus therapiesMedicinal Research ReviewsAshraf M.U., Iman K., Khalid M.F., Salman H.M., Shafi T., Rafi M., Javaid N., Hussain R., Ahmad F., Shahzad-Ul-Hussan S., Mirza S., Shafiq M., Afzal S., Hamera S., Anwar S., Qazi R., Idrees M., Qureshi S.A., Chaudhary S.U.2019
Estimation of hepatitis C prevalence in the Punjab province of Pakistan: A retrospective study on general populationPLoS ONEAhsan A., Khan A.Z., Javed H., Mirza S., Chaudhary S.U., Shahzad-ul-Hussan S.2019
Inhibition of Dengue Virus Protease by Eugeniin, Isobiflorin, and Biflorin Isolated from the Flower Buds of Syzygium aromaticum (Cloves)ACS OmegaSaleem H.N., Batool F., Mansoor H.J., Shahzad-Ul-Hussan S., Saeed M.2019
Potential targets for therapeutic intervention and structure based vaccine design against Zika virusEuropean Journal of Medicinal ChemistryQadir A., Riaz M., Saeed M., Shahzad-ul-Hussan S.2018
CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic GonadotropinPlacenta2018
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV EnvelopeImmunity2018
Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding ProteinsChemBioChemShahzad-ul-Hussan S., Sastry M., Lemmin T., Soto C., Loesgen S., Scott D.A., Davison J.R., Lohith K., O'Connor R., Kwong P.D., Bewley C.A.2017
Phytochemistry of Daphne oleoidesNatural Product ResearchRiaz M., Saleem A., Siddique S., Khan B.A., Nur-E-Alam M., Shahzad-Ul-Hussan S., Miana G.A., Khan M.Q.2016
Treasures hunt in old mines: Terminalia chebula-based traditional herbal medicinal productsNatural Products JournalRiaz M., Asghar A., Rashid R., Shahzad-Ul-Hussan S.2015
Prostratin: An overviewMini-Reviews in Medicinal ChemistryMiana G.A., Riaz M., Shahzad-Ul-Hussan S., Paracha R.Z., Paracha U.Z.2015
Inhibition of hepatitis C virus by the cyanobacterial protein microcystis viridis lectin: Mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNAMolecular PharmaceuticsKachko A., Loesgen S., Shahzad-Ul-Hussan S., Tan W., Zubkova I., Takeda K., Wells F., Rubin S., Bewley C.A., Major M.E.2013
Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopyBiopolymersBewley C.A., Shahzad-Ul-Hussan S.2013
Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16Nature Structural and Molecular Biology2013
Characterization and carbohydrate specificity of pradimicin SJournal of the American Chemical SocietyShahzad-Ul-Hussan S., Ghirlando R., Dogo-Isonagie C.I., Igarashi Y., Balzarini J., Bewley C.A.2012
Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1Journal of Biological ChemistryDogo-Isonagie C., Lam S., Gustchina E., Acharya P., Yang Y., Shahzad-ul-Hussan S., Clore G.M., Kwong P.D., Bewley C.A.2012
Structural basis for norovirus inhibition and fucose mimicry by citrateJournal of Virology2012
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Nature2011
Solution structure of the monovalent lectin microvirin in complex with Man??(1-2)Man provides a basis for anti-HIV activity with low toxicityJournal of Biological ChemistryShahzad-ul-Hussan S., Gustchina E., Ghirlando R., Clore G.M., Bewley C.A.2011
Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVLJournal of the American Chemical SocietyShahzad-ul-Hussan S., Cai M., Bewley C.A.2009
The RNA-bound conformation of neamine as determined by transferred NOE experimentsChemBioChemSzilaghi R., Shahzad-Ul-Hussan S., Weimar T.2005
??-glucosidase inhibitory constituents from Cuscuta reflexaChemical and Pharmaceutical Bulletin2002
New ??-glucosidase inhibitors from the mongolian medicinal plant Ferula mongolicaHelvetica Chimica ActaChoudhary M.I., Baig I., Nur-e-Alam M., Shahzad-ul-Hussan S., Ondognii P., Bunderya M., Oyun Z., Rahman A.-U.2001
Triterpenes from Mimusops elengiZeitschrift fur Naturforschung - Section B Journal of Chemical SciencesJahan N., Malik A., Afza N., Iqbal Choudhary M., Shahzad-ul-Hassan S.2000
Lupene-type triterpenes from Periploca aphyllaJournal of Natural ProductsMustafa G., Anis E., Ahmed S., Anis I., Ahmed H., Malik A., Shahzad-ul-Hassan S., Choudhary M.I.2000