Faculty Profile

Dr. Syed Shahzad ul Hussan

Associate Professor

Department Of Biology

Dr Shahzad ul Hussan joined the Department of Biology at SSE in December 2013 as an Associate Professor. He did his Ph. D. in Bioorganic Chemistry from the University of Luebeck, Germany in 2005. In 2005, he obtained the Postdoctoral Fellowship Award from the National Institutes of Health (NIH), USA and joined the Laboratory of Bioorganic Chemistry at NIDDK, NIH.  During the postdoctoral training his research was focused on NMR structural studies of anti-HIV lectins and understanding the sub-molecular level basis of HIV entry inhibition by those lectins. In 2010, Dr Hussan Joined the Vaccine Research Center of NIAID at NIH as a research fellow where the focus of his research was to study the atomic level details of HIV-surface-displayed-glycan recognition by HIV-1 neutralizing antibodies. His research during last 10 years has resulted in several publications in high-ranking journals namely, Nature, Science, Nature Structural and Molecular Biology, Journal of the American Chemical Society, Journal of Biological Chemistry, Chembiochem and Journal of Virology. His research interests, in general, include understanding the structural properties of ligands in their macromolecular-bound state, the solution structure of proteins and biophysical characterization of recognition phenomenon involving glycans. He has implemented his expertise in understanding the atomic level details of recognition involving viruses. Further details about his current research at his rearch group page at http://biolabs.lums.edu.pk/BSB

Title Publication Author Year
Evolution of efficacious pangenotypic hepatitis C virus therapies Medicinal Research Reviews Ashraf M.U., Iman K., Khalid M.F., Salman H.M., Shafi T., Rafi M., Javaid N., Hussain R., Ahmad F., Shahzad-Ul-Hussan S., Mirza S., Shafiq M., Afzal S., Hamera S., Anwar S., Qazi R., Idrees M., Qureshi S.A., Chaudhary S.U. 2019
Estimation of hepatitis C prevalence in the Punjab province of Pakistan: A retrospective study on general population PLoS ONE Ahsan A., Khan A.Z., Javed H., Mirza S., Chaudhary S.U., Shahzad-ul-Hussan S. 2019
Inhibition of Dengue Virus Protease by Eugeniin, Isobiflorin, and Biflorin Isolated from the Flower Buds of Syzygium aromaticum (Cloves) ACS Omega Saleem H.N., Batool F., Mansoor H.J., Shahzad-Ul-Hussan S., Saeed M. 2019
Potential targets for therapeutic intervention and structure based vaccine design against Zika virus European Journal of Medicinal Chemistry Qadir A., Riaz M., Saeed M., Shahzad-ul-Hussan S. 2018
CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin Placenta Ullah R., Dar S., Ahmad T., de Renty C., Usman M., DePamphilis M.L., Faisal A., Shahzad-ul-Hussan S., Ullah Z. 2018
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope Immunity Zhou T., Zheng A., Baxa U., Chuang G.-Y., Georgiev I.S., Kong R., O'Dell S., Shahzad-ul-Hussan S., Shen C.-H., Tsybovsky Y., Bailer R.T., Gift S.K., Louder M.K., McKee K., Rawi R., Stevenson C.H., Stewart-Jones G.B.E., Taft J.D., Waltari E., Yang Y., Zhang B., Shivatare S.S., Shivatare V.S., Lee C.-C.D., Wu C.-Y., Benjamin B., Blakesley R., Bouffard G., Brooks S., Coleman H., Dekhtyar M., Gregory M., Guan X., Gupta J., Han J., Hargrove A., Ho S., Legaspi R., Maduro Q., Masiello C., Maskeri B., McDowell J., Montemayor C., Mullikin J., Park M., Riebow N., Schandler K., Schmidt B., Sison C., Stantripop M., Thomas J., Thomas P., Vemulapalli M., Young A., Mullikin J.C., Bewley C.A., Burton D.R., Polonis V.R., Shapiro L., Wong C.-H., Mascola J.R., Kwong P.D., Wu X. 2018
Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins ChemBioChem Shahzad-ul-Hussan S., Sastry M., Lemmin T., Soto C., Loesgen S., Scott D.A., Davison J.R., Lohith K., O'Connor R., Kwong P.D., Bewley C.A. 2017
Phytochemistry of Daphne oleoides Natural Product Research Riaz M., Saleem A., Siddique S., Khan B.A., Nur-E-Alam M., Shahzad-Ul-Hussan S., Miana G.A., Khan M.Q. 2016
Treasures hunt in old mines: Terminalia chebula-based traditional herbal medicinal products Natural Products Journal Riaz M., Asghar A., Rashid R., Shahzad-Ul-Hussan S. 2015
Prostratin: An overview Mini-Reviews in Medicinal Chemistry Miana G.A., Riaz M., Shahzad-Ul-Hussan S., Paracha R.Z., Paracha U.Z. 2015
Inhibition of hepatitis C virus by the cyanobacterial protein microcystis viridis lectin: Mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA Molecular Pharmaceutics Kachko A., Loesgen S., Shahzad-Ul-Hussan S., Tan W., Zubkova I., Takeda K., Wells F., Rubin S., Bewley C.A., Major M.E. 2013
Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy Biopolymers Bewley C.A., Shahzad-Ul-Hussan S. 2013
Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16 Nature Structural and Molecular Biology Pancera M., Shahzad-Ul-Hussan S., Doria-Rose N.A., McLellan J.S., Bailer R.T., Dai K., Loesgen S., Louder M.K., Staupe R.P., Yang Y., Zhang B., Parks R., Eudailey J., Lloyd K.E., Blinn J., Alam S.M., Haynes B.F., Amin M.N., Wang L.-X., Burton D.R., Koff W.C., Nabel G.J., Mascola J.R., Bewley C.A., Kwong P.D. 2013
Characterization and carbohydrate specificity of pradimicin S Journal of the American Chemical Society Shahzad-Ul-Hussan S., Ghirlando R., Dogo-Isonagie C.I., Igarashi Y., Balzarini J., Bewley C.A. 2012
Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1 Journal of Biological Chemistry Dogo-Isonagie C., Lam S., Gustchina E., Acharya P., Yang Y., Shahzad-ul-Hussan S., Clore G.M., Kwong P.D., Bewley C.A. 2012
Structural basis for norovirus inhibition and fucose mimicry by citrate Journal of Virology Hansman G.S., Shahzad-ul-Hussan S., McLellan J.S., Chuang G.-Y., Georgiev I., Shimoike T., Katayama K., Bewley C.A., Kwong P.D. 2012
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature McLellan J.S., Pancera M., Carrico C., Gorman J., Julien J.-P., Khayat R., Louder R., Pejchal R., Sastry M., Dai K., O'Dell S., Patel N., Shahzad-Ul-Hussan S., Yang Y., Zhang B., Zhou T., Zhu J., Boyington J.C., Chuang G.-Y., Diwanji D., Georgiev I., Do Kwon Y., Lee D., Louder M.K., Moquin S., Schmidt S.D., Yang Z.-Y., Bonsignori M., Crump J.A., Kapiga S.H., Sam N.E., Haynes B.F., Burton D.R., Koff W.C., Walker L.M., Phogat S., Wyatt R., Orwenyo J., Wang L.-X., Arthos J., Bewley C.A., Mascola J.R., Nabel G.J., Schief W.R., Ward A.B., Wilson I.A., Kwong P.D. 2011
Solution structure of the monovalent lectin microvirin in complex with Man??(1-2)Man provides a basis for anti-HIV activity with low toxicity Journal of Biological Chemistry Shahzad-ul-Hussan S., Gustchina E., Ghirlando R., Clore G.M., Bewley C.A. 2011
Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL Journal of the American Chemical Society Shahzad-ul-Hussan S., Cai M., Bewley C.A. 2009
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: The first inhibitors of GlcNAc-Ins deacetylase Journal of Medicinal Chemistry Metaferia B.B., Fetterolf B.J., Shazad-ul-Hussan S., Moravec M., Smith J.A., Ray S., Gutierrez-Lugo M.-T., Bewley C.A. 2007
The RNA-bound conformation of neamine as determined by transferred NOE experiments ChemBioChem Szilaghi R., Shahzad-Ul-Hussan S., Weimar T. 2005
Inhibition of ??-glucosidase by oleanolic acid and its synthetic derivatives Phytochemistry Ali M.S., Jahangir M., Ul Hussan S.S., Choudhary M.I. 2002
Pharmacological activities of crude acetone extract and purified constituents of Salvia moorcraftiana Wall Phytomedicine Khan T., Zahid M., Asim M., Shahzad-ul-Hussan, Iqbal Z., Choudhary M.I., Ahmad V.U. 2002
??-glucosidase inhibitory constituents from Cuscuta reflexa Chemical and Pharmaceutical Bulletin Anis E., Anis I., Ahmed S., Mustafa G., Malik A., Afza N., Hai S.M.A., Shahzad-Ul-Hussan S., Choudhary M.I. 2002
New ??-glucosidase inhibitors from the mongolian medicinal plant Ferula mongolica Helvetica Chimica Acta Choudhary M.I., Baig I., Nur-e-Alam M., Shahzad-ul-Hussan S., Ondognii P., Bunderya M., Oyun Z., Rahman A.-U. 2001