Dr. Syed Shahzad ul Hussan
Associate Professor
Syed Babar Ali School of Science and Engineering
Dr Shahzad ul Hussan joined the Department of Biology at SSE in December 2013 as an Associate Professor. He did his Ph. D. in Bioorganic Chemistry from the University of Luebeck, Germany in 2005. In 2005, he obtained the Postdoctoral Fellowship Award from the National Institutes of Health (NIH), USA and joined the Laboratory of Bioorganic Chemistry at NIDDK, NIH. During the postdoctoral training his research was focused on NMR structural studies of anti-HIV lectins and understanding the sub-molecular level basis of HIV entry inhibition by those lectins. In 2010, Dr Hussan Joined the Vaccine Research Center of NIAID at NIH as a research fellow where the focus of his research was to study the atomic level details of HIV-surface-displayed-glycan recognition by HIV-1 neutralizing antibodies. His research during last 10 years has resulted in several publications in high-ranking journals namely, Nature, Science, Nature Structural and Molecular Biology, Journal of the American Chemical Society, Journal of Biological Chemistry, Chembiochem and Journal of Virology. His research interests, in general, include understanding the structural properties of ligands in their macromolecular-bound state, the solution structure of proteins and biophysical characterization of recognition phenomenon involving glycans. He has implemented his expertise in understanding the atomic level details of recognition involving viruses. Further details about his current research at his rearch group page at http://biolabs.lums.edu.pk/BSB
| Title | Publication | Author | Year |
|---|---|---|---|
| NMR-Based Metabolomics: A New Paradigm to Unravel Defense-Related Metabolites in Insect-Resistant Cotton Variety through Different Multivariate Data Analysis Approaches | Molecules | 2023 | |
| Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors | Journal of Natural Products | 2022 | |
| RIN4 homologs from important crop species differentially regulate the Arabidopsis NB-LRR immune receptor, RPS2 | Plant Cell Reports | 2021 | |
| H-NMR-based metabolomics: An integrated approach for the detection of the adulteration in chicken, chevon, beef and donkey meat | Molecules | 2021 | |
| Characterization of linear epitope specificity of antibodies potentially contributing to spontaneous clearance of hepatitis C virus | PLoS ONE | 2021 | |
| Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2 | Journal of Structural Biology | 2021 | |
| Identification of potential inhibitors of three key enzymes of SARS-CoV2 using computational approach | Computers in Biology and Medicine | 2020 | |
| Identification of potential inhibitors of three key enzymes of SARS-CoV2 using computational approach | Computers in Biology and Medicine | 2020 | |
| An engineered microvirin variant with identical structural domains potently inhibits human immunodeficiency virus and hepatitis C virus cellular entry | Viruses | 2020 | |
| An engineered microvirin variant with identical structural domains potently inhibits human immunodeficiency virus and hepatitis C virus cellular entry | Viruses | 2020 | |
| Evolution of efficacious pangenotypic hepatitis C virus therapies | Medicinal Research Reviews | 2019 | |
| Evolution of efficacious pangenotypic hepatitis C virus therapies | Medicinal Research Reviews | 2019 | |
| Estimation of hepatitis C prevalence in the Punjab province of Pakistan: A retrospective study on general population | PLoS ONE | 2019 | |
| Estimation of hepatitis C prevalence in the Punjab province of Pakistan: A retrospective study on general population | PLoS ONE | 2019 | |
| Inhibition of Dengue Virus Protease by Eugeniin, Isobiflorin, and Biflorin Isolated from the Flower Buds of Syzygium aromaticum (Cloves) | ACS Omega | 2019 | |
| Inhibition of Dengue Virus Protease by Eugeniin, Isobiflorin, and Biflorin Isolated from the Flower Buds of Syzygium aromaticum (Cloves) | ACS Omega | 2019 | |
| Potential targets for therapeutic intervention and structure based vaccine design against Zika virus | European Journal of Medicinal Chemistry | 2018 | |
| Potential targets for therapeutic intervention and structure based vaccine design against Zika virus | European Journal of Medicinal Chemistry | 2018 | |
| CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin | Placenta | 2018 | |
| CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin | Placenta | 2018 | |
| A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope | Immunity | 2018 | |
| A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope | Immunity | 2018 | |
| Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins | ChemBioChem | 2017 | |
| Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins | ChemBioChem | 2017 | |
| Phytochemistry of Daphne oleoides | Natural Product Research | 2016 | |
| Phytochemistry of Daphne oleoides | Natural Product Research | 2016 | |
| Treasures hunt in old mines: Terminalia chebula-based traditional herbal medicinal products | Natural Products Journal | 2015 | |
| Treasures hunt in old mines: Terminalia chebula-based traditional herbal medicinal products | Natural Products Journal | 2015 | |
| Prostratin: An overview | Mini-Reviews in Medicinal Chemistry | 2015 | |
| Prostratin: An overview | Mini-Reviews in Medicinal Chemistry | 2015 | |
| Inhibition of hepatitis C virus by the cyanobacterial protein microcystis viridis lectin: Mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA | Molecular Pharmaceutics | 2013 | |
| Inhibition of hepatitis C virus by the cyanobacterial protein microcystis viridis lectin: Mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA | Molecular Pharmaceutics | 2013 | |
| Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy | Biopolymers | 2013 | |
| Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy | Biopolymers | 2013 | |
| Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16 | Nature Structural and Molecular Biology | 2013 | |
| Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16 | Nature Structural and Molecular Biology | 2013 | |
| Characterization and carbohydrate specificity of pradimicin S | Journal of the American Chemical Society | 2012 | |
| Characterization and carbohydrate specificity of pradimicin S | Journal of the American Chemical Society | 2012 | |
| Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1 | Journal of Biological Chemistry | 2012 | |
| Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1 | Journal of Biological Chemistry | 2012 | |
| Structural basis for norovirus inhibition and fucose mimicry by citrate | Journal of Virology | 2012 | |
| Structural basis for norovirus inhibition and fucose mimicry by citrate | Journal of Virology | 2012 | |
| Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 | Nature | 2011 | |
| Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 | Nature | 2011 | |
| Solution structure of the monovalent lectin microvirin in complex with Man??(1-2)Man provides a basis for anti-HIV activity with low toxicity | Journal of Biological Chemistry | 2011 | |
| Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL | Journal of the American Chemical Society | 2009 | |
| Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: The first inhibitors of GlcNAc-Ins deacetylase | Journal of Medicinal Chemistry | 2007 | |
| Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4 | Science | 2007 | |
| The RNA-bound conformation of neamine as determined by transferred NOE experiments | ChemBioChem | 2005 | |
| Inhibition of ??-glucosidase by oleanolic acid and its synthetic derivatives | Phytochemistry | 2002 | |
| Pharmacological activities of crude acetone extract and purified constituents of Salvia moorcraftiana Wall | Phytomedicine | 2002 |