Dr. Saleem is employing the skills of organic synthesis in designing drugs of the future and in developing organic dyes for light harvestation by solar cells. He joined LUMS in 2012 and since then he has been actively applying his organic synthesis to various applications that include developing The Drug Discovery Labs at LUMS. He is interested in the synthesis of the libraries of novel molecules that could modulate various cellular proteins involved in the cell cycle (notably kinases (Aurora kinases), centrosome clustering, Phosphohistonase 3P, MDM2-p53, AAA+ ATPase & 12-TM), development of new methodologies to access novel scafolds, novel ligands for nanoparticle and the isolation, characterization & synthesis of the natural products of biological importance and food & toxicology. He is also interested in the organic dyes for dye-sensitized solar cells.
Dr. Saleem is keen to explore the collaborative endeavors across the universities to advance the scientific output and is always willing to help the students. He also takes care of the chromatographic facility (LC-MS) at LUMS.
Earlier, Dr. Rahman Saleem obtained his M.Sc. in Chemistry from GC University, Lahore, Pakistan with distinction (Gold Medal and Academic Role of Honor) in 2002 and MPhil in Chemistry in 2004. He served in GC University, Lahore for an academic year and then in Gujranwala Institute of Future Technologies as lecturer for three years. During this time he was awarded Orient Dr. Ata-ur-Rehman Chemistry Award & XIVth Star Award and was selected to present Pakistan in the 56th Meeting with Nobel Laureates in Lindau, Germany. In 2006, he obtained Fulbright scholarship for PhD studies at Michigan State University, USA. There, he worked, in the labs of Prof. Dr. Jetze Tepe, at the interface of chemistry and biology and focused on various research projects aimed towards cancer research. During his PhD, Dr. Saleem synthesized natural products and their analogs aimed at inhibiting check point kinase 2 and imidazoline based inhibitors of NF-κB pathway to study their binding interaction with proteasome 26s, developed the methodology for the synthesis of 1,2,4-triazoline and 1,2,4-triazoles via [2+3]-cycloaddition reactions of oxazolones and prepared photoaffinity labelled molecules to study the drug protein interaction. He completed his PhD in Chemistry in 2011 and returned to Pakistan. In the summer of 2012, he visited University of Bristol as visiting faculty and in 2014, he visited University of Cambridge as Herchel Smith fellow. Dr. Saleem, during his time in LUMS, has completed two research projects. He has presented his research work in various international and national conferences including the US National Organic Symposium.