Faculty Profile

Dr. Rahman Shah Zaib Saleem

Assistant Professor

Chemistry & Chemical Engineering

Dr. Saleem is employing organic synthesis to prepare compounds for application in the areas of medicinal chemistry and materials. In the medicinal chemistry, his current focus is in the area of cancer research (targeting p53-MDM2 interaction, centrosome clustering and tubulin polymerization inhibition), diabetes research, preparation of novel metal-free organic dyes for solar cell and organic scaffolds for metal organic frameworks (MOFs). Other interests include national product isolation and identification and analysis of food for toxicology studies.

Dr. Saleem completed his doctoral studies in synthetic organic/medicinal chemistry from the Michigan State University as Fulbright Scholar in 2011. His doctoral work corresponded to the development of novel dipolar cycloaddition methodology, synthesis of natural product (Hymenialdisine) and preparation of inhibitors of check-point kinase 2 and NF-KappaB. His postdoctoral visit to University of Bristol involve synthesis of novel AAA+ ATPase modulators. His postdoctoral stay at the University of Cambridge involved synthesis of the protein-protein-interaction modulators and his recent visit to University of Saarland as DAAD fellow involved synthesis of selenium containing redox modulators. Earlier, Dr. Rahman Saleem obtained his M.Sc. in Chemistry from GC University, Lahore, Pakistan with distinction (Gold Medal and Academic Role of Honor) in 2002 and MPhil in Chemistry in 2004. He served in GC University, Lahore for an academic year and then in Gujranwala Institute of Future Technologies as lecturer for three years. During this time he was awarded Orient Dr. Ata-ur-Rehman Chemistry Award & XIVth Star Award and was selected to present Pakistan in the 56th Meeting with Nobel Laureates in Lindau, Germany.  Dr. Saleem, during his time in LUMS, has completed three research projects and has presented hiss research work in various international and national conferences including the US National Organic Symposium.


Research Group Website

    • Article
      • Saleem, R. S. Z. .(1999). Synthesis of 1, 2, 4-triazolines and triazoles utilizing oxazolones . ,
      • Saleem, R. S. Z. .(1999). Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors . ,
      • Saleem, R. S. Z. .(1999). Radioprotection by Hymenialdisine-Derived Checkpoint Kinase 2 Inhibitors . ,
      • Saleem, R. S. Z. .(1999). Lahorenoic Acids A-C, ortho-Dialkyl-Substituted Aromatic Acids from the Biocontrol Strain Pseudomonas aurantiaca PB-St2 . ,
      • Saleem, R. S. Z. .(1999). 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid . ,
      • Saleem, R. S. Z. .(1999). Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel . ,
      • Saleem, R. S. Z. .(1999). Heterocyclic Interconversion of Oxazolones into Triazolinesand Triazoles . ,
    • Journal Articles
      • Saleem, R. S. Z. .(2014). A concise total synthesis of hymenialdisine . Tetrahedron Letters , Elsevier
    • Conference Papers
      • Saleem, R. S. Z. Efficient Synthesis Of Marine Alkaloid: Hymenialdisine- A Potential Lead In The Drug Discovery . International Conference on Emerging Trends in Life Sciences for Sustainable Development , Forman Christian College (A Chartered University)
      • Saleem, R. S. Z. Debromohymenialdine analogs- A SAR study for ChK2 vs ChK1 selectivity . Chemical Trends 2014- A conference on the recent trends in chemical research , Lahore University of Management Sciences
    • Research Paper
      • Saleem, R. S. Z. Isolation and Characterization of secondary metabolites produced by rhizobacteria and their potential as biocontrol agents . Grant of about PKR 9M submitted to HEC as Co-PI Status: Approved ,
Chemistry of the Organic Functional GroupsFall Semester 2014-151401
Organic Chemistry Lab IIFall Semester 2014-151401
Senior Project IFall Semester 2014-151401
Chemical Problems & ReportsFall Semester 2014-151401
Doctoral Thesis ResearchFall Semester 2014-151401
Master's Thesis IFall Semester 2014-151401
Advanced Organic ChemistrySpring Semester 2014-151402
Senior Project IISpring Semester 2014-151402
Directed Research ProjectSpring Semester 2014-151402
Chemistry Literature SeminarSpring Semester 2014-151402
Doctoral Thesis ResearchSpring Semester 2014-151402
Master's Thesis IISpring Semester 2014-151402
Chemistry of the Organic Functional GroupsFall Semester 2015-161501
Organic Chemistry Lab IIFall Semester 2015-161501
Senior Project IFall Semester 2015-161501
Chemistry SeminarFall Semester 2015-161501
Master's Thesis IFall Semester 2015-161501
Senior Project IISpring Semester 2015-161502
Chemical Problems & ReportsSpring Semester 2015-161502
Organic SpectroscopySpring Semester 2015-161502
Directed Research ProjectSpring Semester 2015-161502
Master's Thesis IISpring Semester 2015-161502
Doctoral Thesis ResearchSummer Semester 2015-161503
Chemistry of the Organic Functional GroupsFall Semester 2016-171601
Organic Chemistry Lab IIFall Semester 2016-171601
Senior Project IFall Semester 2016-171601
Chemistry Literature SeminarFall Semester 2016-171601
Doctoral Thesis ResearchFall Semester 2016-171601
Master's Thesis IFall Semester 2016-171601
Senior Project IISpring Semester 2016-171602
Organic SpectroscopySpring Semester 2016-171602
Chemistry Literature SeminarSpring Semester 2016-171602
Doctoral Thesis ResearchSpring Semester 2016-171602
Master's Thesis IISpring Semester 2016-171602
Doctoral Thesis ResearchSummer Semester 2016-171603
Chemistry of the Organic Functional GroupsFall Semester 2017-181701
Organic Chemistry Lab IIFall Semester 2017-181701
Chemistry Literature SeminarFall Semester 2017-181701
  • Past Courses
    Advanced Organic ChemistrySpring Semester 2011-121102
    Organic Chemistry Lab IIFall Semester 2012-131201
    Senior Project IFall Semester 2012-131201
    Introduction to Drug Discovery and DevelopmentFall Semester 2012-131201
    Spectroscopy - Theory & ApplicationsSpring Semester 2012-131202
    Advanced Organic ChemistrySpring Semester 2012-131202
    Senior Project IISpring Semester 2012-131202
    Organic Chemistry Lab IIFall Semester 2013-141301
    Senior Project IFall Semester 2013-141301
    Chemical Problems & ReportsFall Semester 2013-141301
    Advanced Organic ChemistrySpring Semester 2013-141302
    Independent StudySpring Semester 2013-141302
    Senior Project IISpring Semester 2013-141302
    RetrosynthesisSpring Semester 2013-141302
    Chemistry SeminarSpring Semester 2013-141302
    Organic SynthesisSpring Semester 2013-141302
    Directed Research ProjectSpring Semester 2013-141302
    Doctoral Thesis ResearchSummer Semester 2013-141303