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Dr. Rahman Shah Zaib Saleem
Associate Professor
Syed Babar Ali School of Science and Engineering
rahman.saleem@lums.edu.pk
  • Profile
  • Conferences, Publications and Journal Articles

Research group page: OrgChem.lums.edu.pk
Google Scholar: https://scholar.google.com.pk/citations?hl=en&user=dGv6WBMAAAAJ&view_op=list_works&sortby=pubdate
LinkedIn: https://www.linkedin.com/in/rahman-shah-zaib-saleem-b0984734/
Twitter: https://twitter.com/RahmanSZSaleem
Facebook: https://www.facebook.com/rahman.saleem/

Bio:
Dr. Rahman Shah Zaib Saleem joined LUMS in 2012 as an assistant professor and was tenured and promoted to associate professor in 2020.  He is an enthusiastic experienced organic chemist with a proven track record in medicinal chemistry and materials. He enjoys teaching and training organic chemistry, spectroscopy, medicinal chemistry and drug discovery courses to undergraduate and postgraduate students. He builds effective collaborations within and outside of the institution.


In medicinal chemistry, he has expertise in the discovery of lead molecules for various cellular targets. His specialties include hit and lead generation, lead optimization, medicinal chemistry, organic synthesis and methodology, structure-based drug design, data analysis, natural product isolation and structure elucidation.


On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) and modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of natural products.

Post-doctoral/Work experience
Jan 2020- to date     Associate Professor (tenure), Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Jan 2012- Jan 2020     Assistant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2019    DAAD fellow, University of Saarland, Germany
Summer 2016    DAAD fellow, University of Saarland, Germany
Summer 2014    Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012    Post-Doctoral Research Visit, University of Bristol, UK

 

Education
2011      PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004      MPhil, GC University, Lahore, Pakistan
2002      MSc, GC University, Lahore, Pakistan (First position in the university)
2000      BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan


Roll of Honors
Academic roll of honor (2002)

 

Awards
2019                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2016                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14                Herchel Smith fellowship, University of Cambridge
2012                     LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11                Fulbright PhD fellowship
2011                     Dissertation completion fellowship
2011                     Graduation school travel fellowship, Michigan State University
2006                     Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006                     XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003                     Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002                     Academic excellence award, GC University Lahore
2002                     Prof. Abdul Rashid Tariq gold medal
1998                     President talent farming award
1996                     Jamiat gold medal

Title Publication Author Year
Synthesis, photophysical, voltammetric, and DFT studies of 4-aminochalones Journal of Photochemistry and Photobiology A: Chemistry 2023
Potent heteroaromatic hydrazone based 1,2,4-triazine motifs: synthesis, anti-oxidant activity, cholinesterase inhibition, quantum chemical and molecular docking studies Journal of Molecular Structure 2023
Perplexing Polyphenolics: The Isolations, Syntheses, Reappraisals, and Bioactivities of Flavonoids, Isoflavonoids, and Neoflavonoids from 2016 to 2022 Life 2023
Centrosome Clustering & Chemotherapy Mini-Reviews in Medicinal Chemistry 2023
Selenium-containing Peptides and their Biological Applications Current Medicinal Chemistry 2022
Synthesis and Characterization of Griseofulvin Derivatives as Microtubule-Stabilizing Agents ChemistrySelect 2022
Indole-Containing Natural Products 2019???2022: Isolations, Reappraisals, Syntheses, and Biological Activities Molecules 2022
Synthesis, photophysical, electrochemical and computational studies of novel 2-aminoimidazolones with D-??-A framework Journal of Photochemistry and Photobiology A: Chemistry 2022
Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors Journal of Natural Products 2022
Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity Pharmaceutical Chemistry Journal 2022
Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells ChemistrySelect 2022
Iridium-Catalyzed C-H Borylation of CF<inf>3</inf>-Substituted Pyridines ACS Omega 2022
Synthesis and evaluation of novel 1, 2, 4-substituted triazoles for urease and anti-proliferative activity Pakistan Journal of Pharmaceutical Sciences 2022
Synthesis, Spectral Evaluation and in Silico Studies of S-Aralkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols: As suitable Alzheimer's disease drug candidates Journal of the Chemical Society of Pakistan 2021
Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel acetylcholinesterase and butyrylcholinesterase inhibitors Journal of Molecular Structure 2021
Structure Dependent Differential Modulation of A?? Fibrillization by Selenadiazole-Based Inhibitors ACS Chemical Neuroscience 2021
CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells British Journal of Cancer 2021
In Silico Validation, Fabrication and Evaluation of Nano-Liposomes of Bistorta amplexicaulis Extract for Improved Anticancer Activity Against Hepatoma Cell Line (HepG2) Current Drug Delivery 2021
Detection of aflatoxin M1 by fiber cavity attenuated phase shift spectroscopy Optics Express 2021
Plants as a promising reservoir of tyrosinase inhibitors Mini-Reviews in Organic Chemistry 2021
A comprehensive review of aminochalcones Molecules 2020
Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors Journal of Natural Products 2020
Recent advances in synthesis of organometallic complexes of indium Reviews in Inorganic Chemistry 2020
Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study ChemistrySelect 2020
Facile synthesis of NH-free 5-(hetero)aryl-pyrrole-2-carboxylates by catalytic C-H borylation and suzuki coupling Molecules 2020

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