Faculty Profile
Dr. Rahman Shah Zaib Saleem
Assistant Professor
Department Of Chemistry & Chemical Engineering
Dr. Rahman Shah Zaib Saleem is employing organic chemistry tools in designing the drugs of the future and in materials. He joined LUMS in 2012 as an assistant professor. He has been interested in the development of organic methodology as well as the synthesis of the compound libraries to modulate various cellular proteins involved in the cell cycle (notably kinases, centrosome clustering, Phosphohistonase 3P, MDM2-p53, tubulin, hIAPP). On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) as well as the modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of the natural products.
Post-doctoral/Work experience
2012- to date Assitant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2016 DAAD fellow, University of Saarland, Germany
Summer 2014 Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012 Post-Doctoral Research Visit, University of Bristol, UK
Education
2011 PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004 MPhil, GC University, Lahore, Pakistan
2002 MSc, GC University, Lahore, Pakistan (First position in the university)
2000 BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan
Roll of Honors
Academic roll of honor (2002)
Awards
2016 DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14 Herchel Smith fellowship, University of Cambridge
2012 LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11 Fulbright PhD fellowship
2011 Dissertation completion fellowship
2011 Graduation school travel fellowship, Michigan State University
2006 Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006 XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003 Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002 Academic excellence award, GC University Lahore
2002 Prof. Abdul Rashid Tariq gold medal
1998 President talent farming award
1996 Jamiat gold medal
Chemical Geneology
Guillaume Francois Rouelle (1703-1770) (Apothecary 1725, Paris)
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+Antoine Laurent Lavoisier (1743-1794) (LLB 1764, Paris)
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+Jean Baptiste Michel Bucquet (1746-1780) (MD 1770, Paris)
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+Antoine Francois de Fourcroy (1755-1809) (MD 1780, Paris)
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+Louis Nicolas Vauquelin (1763-1829) (MA 1790, Paris)
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+Louis Jacques Thenard (1777-1857) (MA 1797, Paris)
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+Jean Baptiste Andre Dumas (1800-1884) (none 1823, Geneva)
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+Josiah Parsons Cooke (1827-1894) (AB 1848, Harvard)
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+Charles Loring Jackson (1847-1935) (MA 1871, Harvard)
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+Henry Augustus Torrey (1871-1910) (PhD 1897, Harvard)
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+Roger Adams (1889-1971) (PhD 1912, Harvard)
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+Samuel Marion McElvain (1897-1973) (PhD – BioChem 1923, Illinois)
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+Gilbert J Stork (1921-____) (PhD 1946, Wisconsin)
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+Timothy Lee MacDonald (____-____) (PhD 1975, Columbia)
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+Jetze J Tepe (1968-____) (PhD 1998, Virginia) (MSU 2000-____)
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+Rahman Shah Zaib Saleem (____-____) (PhD 2011, MSU) (LUMS 2012-____)
| Title | Publication | Author | Year |
|---|---|---|---|
| Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells | Iranian Journal of Science and Technology, Transaction A: Science | Batool S., Ullah S., Tabassum S., Bilal A., Faisal A., Saleem R.S.Z., Ahmad M.S. | 2019 |
| Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance | Bioorganic Chemistry | Riaz S., Iqbal M., Ullah R., Zahra R., Chotana G.A., Faisal A., Saleem R.S.Z. | 2019 |
| Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation | Bioorganic Chemistry | Farrukh S.U.B., Javed I., Ather A.Q., Emwas A.-H., Alazmi M., Gao X., Chotana G.A., Davis T.P., Ke P.C., Saleem R.S.Z. | 2019 |
| A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-Aminoimidazolone Derivatives | ChemistrySelect | Hanif A., Sardar A., Alazmi M., Tariq H., Emwas A.-H., Gao X., Chotana G.A., Zaib Saleem R.S. | 2019 |
| Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance | Scientific Reports | 2018 | |
| Synthesis, in vitro and in silico studies of S-alkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as cholinesterase inhibitors | Pakistan journal of pharmaceutical sciences | Arfan M., Siddiqui S.Z., Abbasi M.A., Rehman A., Shah S.A.A., Ashraf M., Rehman J., Saleem R.S.Z., Khalid H., Hussain R., Khan U. | 2018 |
| Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls | Synthesis (Germany) | 2018 | |
| Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) | Scientific reports | 2018 | |
| Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation | Synthesis (Germany) | 2018 | |
| The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activity | Current Organic Synthesis | Rendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M. | 2017 |
| Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grass | Journal of Microbiology and Biotechnology | 2017 | |
| Synthesis and evaluation of modified chalcone based p53 stabilizing agents | Bioorganic and Medicinal Chemistry Letters | Iftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z. | 2017 |
| Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel | Journal of Materials Chemistry B | Sohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G. | 2016 |
| A concise total synthesis of hymenialdisine | Tetrahedron Letters | 2015 | |
| Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2 | Journal of Natural Products | Mehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G. | 2013 |
| Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors | Bioorganic and Medicinal Chemistry | Saleem R.S.Z., Lansdell T.A., Tepe J.J. | 2012 |
| Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors | ACS Chemical Biology | Nguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J. | 2012 |
| Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones | Journal of Organic Chemistry | Saleem R.S.Z., Tepe J.J. | 2010 |
| 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid | Acta Crystallographica Section E: Structure Reports Online | 2008 |