Faculty Profile

Dr. Rahman Shah Zaib Saleem

Assistant Professor

Department Of Chemistry & Chemical Engineering

Dr. Saleem is employing organic synthesis to prepare compounds for application in the areas of medicinal chemistry and materials. In the medicinal chemistry, his current focus is in the area of cancer research (targeting p53-MDM2 interaction, centrosome clustering and tubulin polymerization inhibition), diabetes research, preparation of novel metal-free organic dyes for solar cell and organic scaffolds for metal organic frameworks (MOFs). Other interests include national product isolation and identification and analysis of food for toxicology studies.

Dr. Saleem completed his doctoral studies in synthetic organic/medicinal chemistry from the Michigan State University as Fulbright Scholar in 2011. His doctoral work corresponded to the development of novel dipolar cycloaddition methodology, synthesis of natural product (Hymenialdisine) and preparation of inhibitors of check-point kinase 2 and NF-KappaB. His postdoctoral visit to University of Bristol involve synthesis of novel AAA+ ATPase modulators. His postdoctoral stay at the University of Cambridge involved synthesis of the protein-protein-interaction modulators and his recent visit to University of Saarland as DAAD fellow involved synthesis of selenium containing redox modulators. Earlier, Dr. Rahman Saleem obtained his M.Sc. in Chemistry from GC University, Lahore, Pakistan with distinction (Gold Medal and Academic Role of Honor) in 2002 and MPhil in Chemistry in 2004. He served in GC University, Lahore for an academic year and then in Gujranwala Institute of Future Technologies as lecturer for three years. During this time he was awarded Orient Dr. Ata-ur-Rehman Chemistry Award & XIVth Star Award and was selected to present Pakistan in the 56th Meeting with Nobel Laureates in Lindau, Germany.  Dr. Saleem, during his time in LUMS, has completed three research projects and has presented hiss research work in various international and national conferences including the US National Organic Symposium.

 

Research Group Website

TitlePublicationAuthorYear
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistanceScientific ReportsManzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A.2018
Iridium-Catalyzed Regioselective Borylation of Substituted BiarylsSynthesis (Germany)Asghar S., Shahzadi T., Alazmi M., Gao X., Emwas A.-H., Saleem R.S.Z., Batool F., Chotana G.A.2018
The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activityCurrent Organic SynthesisRendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M.2017
Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grassJournal of Microbiology and BiotechnologyShahid I., Rizwan M., Baig D.N., Saleem R.S., Malik K.A., Mehnaz S.2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agentsBioorganic and Medicinal Chemistry LettersIftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z.2017
Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxelJournal of Materials Chemistry BSohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G.2016
A concise total synthesis of hymenialdisineTetrahedron LettersSaleem R.S.Z., J. Tepe J.2015
Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2Journal of Natural ProductsMehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G.2013
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitorsBioorganic and Medicinal ChemistrySaleem R.S.Z., Lansdell T.A., Tepe J.J.2012
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitorsACS Chemical BiologyNguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J.2012
Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolonesJournal of Organic ChemistrySaleem R.S.Z., Tepe J.J.2010
5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acidActa Crystallographica Section E: Structure Reports OnlineZia-Ur-Rehman M., Elsegood M.R.J., Akbar N., Shah Zaib Saleem R.2008
SemesterTitleCode
Fall Semester 2018-19Master's Thesis1801
Fall Semester 2018-19Senior Project1801
Fall Semester 2018-19Chemistry Literature Seminar1801
Fall Semester 2018-19Chemistry of the Organic Functional Groups1801
Fall Semester 2018-19Independent Study1801
Summer Semester 2017-18Doctoral Thesis Research1703
Spring Semester 2017-18Master's Thesis1702
Spring Semester 2017-18Chemistry Seminar1702
Spring Semester 2017-18Organic Spectroscopy1702
Spring Semester 2017-18Chemical Problems & Reports1702
Spring Semester 2017-18Organic Chemistry Lab II1702
Fall Semester 2017-18Master's Thesis1701
Fall Semester 2017-18Doctoral Thesis Research1701
Fall Semester 2017-18Chemistry Literature Seminar1701
Fall Semester 2017-18Organic Chemistry Lab II1701
Fall Semester 2017-18Chemistry of the Organic Functional Groups1701
Summer Semester 2016-17Doctoral Thesis Research1603
Spring Semester 2016-17Master's Thesis II1602
Spring Semester 2016-17Doctoral Thesis Research1602
Spring Semester 2016-17Chemistry Literature Seminar1602
Spring Semester 2016-17Organic Spectroscopy1602
Spring Semester 2016-17Senior Project II1602
Fall Semester 2016-17Master's Thesis I1601
Fall Semester 2016-17Doctoral Thesis Research1601
Fall Semester 2016-17Chemistry Literature Seminar1601
Fall Semester 2016-17Senior Project I1601
Fall Semester 2016-17Organic Chemistry Lab II1601
Fall Semester 2016-17Chemistry of the Organic Functional Groups1601
Summer Semester 2015-16Doctoral Thesis Research1503
Spring Semester 2015-16Master's Thesis II1502
Spring Semester 2015-16Directed Research Project1502
Spring Semester 2015-16Organic Spectroscopy1502
Spring Semester 2015-16Chemical Problems & Reports1502
Spring Semester 2015-16Senior Project II1502
Fall Semester 2015-16Master's Thesis I1501
Fall Semester 2015-16Chemistry Seminar1501
Fall Semester 2015-16Senior Project I1501
Fall Semester 2015-16Organic Chemistry Lab II1501
Fall Semester 2015-16Chemistry of the Organic Functional Groups1501
Spring Semester 2014-15Master's Thesis II1402
Spring Semester 2014-15Doctoral Thesis Research1402
Spring Semester 2014-15Chemistry Literature Seminar1402
Spring Semester 2014-15Directed Research Project1402
Spring Semester 2014-15Senior Project II1402
Spring Semester 2014-15Advanced Organic Chemistry1402
Fall Semester 2014-15Master's Thesis I1401
Fall Semester 2014-15Doctoral Thesis Research1401
Fall Semester 2014-15Chemical Problems & Reports1401
Fall Semester 2014-15Senior Project I1401
Fall Semester 2014-15Organic Chemistry Lab II1401
Fall Semester 2014-15Chemistry of the Organic Functional Groups1401
  • Past Courses
    SemesterTitleCode
    Summer Semester 2013-14Doctoral Thesis Research1303
    Spring Semester 2013-14Directed Research Project1302
    Spring Semester 2013-14Organic Synthesis1302
    Spring Semester 2013-14Chemistry Seminar1302
    Spring Semester 2013-14Retrosynthesis1302
    Spring Semester 2013-14Senior Project II1302
    Spring Semester 2013-14Independent Study1302
    Spring Semester 2013-14Advanced Organic Chemistry1302
    Fall Semester 2013-14Chemical Problems & Reports1301
    Fall Semester 2013-14Senior Project I1301
    Fall Semester 2013-14Organic Chemistry Lab II1301
    Spring Semester 2012-13Senior Project II1202
    Spring Semester 2012-13Advanced Organic Chemistry1202
    Spring Semester 2012-13Spectroscopy - Theory & Applications1202
    Fall Semester 2012-13Introduction to Drug Discovery and Development1201
    Fall Semester 2012-13Senior Project I1201
    Fall Semester 2012-13Organic Chemistry Lab II1201
    Spring Semester 2011-12Advanced Organic Chemistry1102