Dr. Saleem joined LUMS in 2012 as an assistant professor and was tenured and promoted to associate professor in 2020. He is an enthusiastic experienced organic chemist with a proven track record in the medicinal chemistry and materials. He enjoys teaching and training organic chemistry, spectroscopy, medicinal chemistry and drug discovery courses at undergraduate and postgraduate level. He builds effective collaborations within and outside of the institution.
In the medicinal chemistry, he has expertise in the discovery of lead molecules for various cellular targets. His specialties include hit and lead generation, lead optimization, medicinal chemistry, organic synthesis and methodology, structure-based drug design, data analysis, natural product isolation and structure elucidation.
On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) and modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of the natural products.
Post-doctoral/Work experience
Jan 2020- to date Associate Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Jan 2012- Jan 2020 Assistant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2019 DAAD fellow, University of Saarland, Germany
Summer 2016 DAAD fellow, University of Saarland, Germany
Summer 2014 Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012 Post-Doctoral Research Visit, University of Bristol, UK
Education
2011 PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004 MPhil, GC University, Lahore, Pakistan
2002 MSc, GC University, Lahore, Pakistan (First position in the university)
2000 BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan
Roll of Honors
Academic roll of honor (2002)
Awards
2019 DAAD Research Stays for University Academics and Scientists, University of Saarland
2016 DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14 Herchel Smith fellowship, University of Cambridge
2012 LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11 Fulbright PhD fellowship
2011 Dissertation completion fellowship
2011 Graduation school travel fellowship, Michigan State University
2006 Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006 XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003 Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002 Academic excellence award, GC University Lahore
2002 Prof. Abdul Rashid Tariq gold medal
1998 President talent farming award
1996 Jamiat gold medal
Research group page: OrgChem.lums.edu.pk
| Title | Publication | Author | Year |
|---|---|---|---|
| Recent advances in synthesis of organometallic complexes of indium | Reviews in Inorganic Chemistry | 2020 | |
| Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study | ChemistrySelect | 2020 | |
| A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)mediated multidrug resistance | PLoS ONE | 2020 | |
| Facile synthesis of NH-free 5-(hetero)aryl-pyrrole-2-carboxylates by catalytic C-H borylation and suzuki coupling | Molecules | 2020 | |
| Biosynthesis of zno nanoparticles using ocimum basilicum and determination of its antimicrobial activity | Journal of Animal and Plant Sciences | 2020 | |
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors | Journal of Natural Products | 2020 | |
| Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells | Iranian Journal of Science and Technology, Transaction A: Science | 2019 | |
| Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance | Bioorganic Chemistry | 2019 | |
| Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation | Bioorganic Chemistry | 2019 | |
| A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-Aminoimidazolone Derivatives | ChemistrySelect | 2019 | |
| Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity | Pakistan Journal of Pharmaceutical Sciences | 2019 | |
| Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance | Scientific Reports | 2018 | |
| Synthesis, in vitro and in silico studies of S-alkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as cholinesterase inhibitors | Pakistan journal of pharmaceutical sciences | 2018 | |
| Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls | Synthesis (Germany) | 2018 | |
| Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) | Scientific reports | 2018 | |
| Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation | Synthesis (Germany) | 2018 | |
| The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activity | Current Organic Synthesis | 2017 | |
| Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grass | Journal of Microbiology and Biotechnology | 2017 | |
| Synthesis and evaluation of modified chalcone based p53 stabilizing agents | Bioorganic and Medicinal Chemistry Letters | 2017 | |
| Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel | Journal of Materials Chemistry B | 2016 | |
| A concise total synthesis of hymenialdisine | Tetrahedron Letters | 2015 | |
| Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2 | Journal of Natural Products | 2013 | |
| Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors | Bioorganic and Medicinal Chemistry | 2012 | |
| Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors | ACS Chemical Biology | 2012 | |
| Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones | Journal of Organic Chemistry | 2010 |