Faculty Profile

Dr. Rahman Shah Zaib Saleem

Assistant Professor

Department Of Chemistry & Chemical Engineering

Dr. Saleem is employing organic synthesis to prepare compounds for application in the areas of medicinal chemistry and materials. In the medicinal chemistry, his current focus is in the area of cancer research (targeting p53-MDM2 interaction, centrosome clustering and tubulin polymerization inhibition), diabetes research, preparation of novel metal-free organic dyes for solar cell and organic scaffolds for metal organic frameworks (MOFs). Other interests include national product isolation and identification and analysis of food for toxicology studies.

Dr. Saleem completed his doctoral studies in synthetic organic/medicinal chemistry from the Michigan State University as Fulbright Scholar in 2011. His doctoral work corresponded to the development of novel dipolar cycloaddition methodology, synthesis of natural product (Hymenialdisine) and preparation of inhibitors of check-point kinase 2 and NF-KappaB. His postdoctoral visit to University of Bristol involve synthesis of novel AAA+ ATPase modulators. His postdoctoral stay at the University of Cambridge involved synthesis of the protein-protein-interaction modulators and his recent visit to University of Saarland as DAAD fellow involved synthesis of selenium containing redox modulators. Earlier, Dr. Rahman Saleem obtained his M.Sc. in Chemistry from GC University, Lahore, Pakistan with distinction (Gold Medal and Academic Role of Honor) in 2002 and MPhil in Chemistry in 2004. He served in GC University, Lahore for an academic year and then in Gujranwala Institute of Future Technologies as lecturer for three years. During this time he was awarded Orient Dr. Ata-ur-Rehman Chemistry Award & XIVth Star Award and was selected to present Pakistan in the 56th Meeting with Nobel Laureates in Lindau, Germany.  Dr. Saleem, during his time in LUMS, has completed three research projects and has presented hiss research work in various international and national conferences including the US National Organic Symposium.

 

Research Group Website

TitlePublicationAuthorYear
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistanceScientific ReportsManzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A.2018
Iridium-Catalyzed Regioselective Borylation of Substituted BiarylsSynthesis (Germany)Asghar S., Shahzadi T., Alazmi M., Gao X., Emwas A.-H., Saleem R.S.Z., Batool F., Chotana G.A.2018
Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and OxidationSynthesis (Germany)Shahzadi T., Saleem R.S.Z., Chotana G.A.2018
The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activityCurrent Organic SynthesisRendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M.2017
Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grassJournal of Microbiology and BiotechnologyShahid I., Rizwan M., Baig D.N., Saleem R.S., Malik K.A., Mehnaz S.2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agentsBioorganic and Medicinal Chemistry LettersIftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z.2017
Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxelJournal of Materials Chemistry BSohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G.2016
A concise total synthesis of hymenialdisineTetrahedron LettersSaleem R.S.Z., J. Tepe J.2015
Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2Journal of Natural ProductsMehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G.2013
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitorsBioorganic and Medicinal ChemistrySaleem R.S.Z., Lansdell T.A., Tepe J.J.2012
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitorsACS Chemical BiologyNguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J.2012
Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolonesJournal of Organic ChemistrySaleem R.S.Z., Tepe J.J.2010
5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acidActa Crystallographica Section E: Structure Reports OnlineZia-Ur-Rehman M., Elsegood M.R.J., Akbar N., Shah Zaib Saleem R.2008