Faculty Profile

Dr. Rahman Shah Zaib Saleem

Assistant Professor

Department Of Chemistry & Chemical Engineering

Dr. Rahman Shah Zaib Saleem is employing organic chemistry tools in designing the drugs of the future and in materials. He joined LUMS in 2012 as an assistant professor. He has been interested in the development of organic methodology as well as the synthesis of the compound libraries to modulate various cellular proteins involved in the cell cycle (notably kinases, centrosome clustering, Phosphohistonase 3P, MDM2-p53, tubulin, hIAPP). On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) as well as the modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of the natural products.

Post-doctoral/Work experience

2012- to date     Assitant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS

Summer 2016    DAAD fellow, University of Saarland, Germany

Summer 2014    Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK

Summer 2012    Post-Doctoral Research Visit, University of Bristol, UK

Education

2011      PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)

2004      MPhil, GC University, Lahore, Pakistan

2002      MSc, GC University, Lahore, Pakistan (First position in the university)

2000      BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan

Roll of Honors

Academic roll of honor (2002)

Awards

2016                     DAAD Research Stays for University Academics and Scientists, University of Saarland

2013-14                Herchel Smith fellowship, University of Cambridge

2012                     LUMS’ SSE Deans travel award for the summer research visit to University of Bristol

2006-11                Fulbright PhD fellowship

2011                     Dissertation completion fellowship

2011                     Graduation school travel fellowship, Michigan State University

2006                     Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University

2006                     XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium

2003                     Orient Dr. Ata-ur-Rehman chemistry award and gold medal

2002                     Academic excellence award, GC University Lahore

2002                     Prof. Abdul Rashid Tariq gold medal

1998                     President talent farming award

1996                     Jamiat gold medal

Chemical Geneology

Guillaume Francois Rouelle (1703-1770) (Apothecary 1725, Paris)
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+Antoine Laurent Lavoisier (1743-1794) (LLB 1764, Paris)
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+Jean Baptiste Michel Bucquet (1746-1780) (MD 1770, Paris)
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+Antoine Francois de Fourcroy (1755-1809) (MD 1780, Paris)
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+Louis Nicolas Vauquelin (1763-1829) (MA 1790, Paris)
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+Louis Jacques Thenard (1777-1857) (MA 1797, Paris)
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+Jean Baptiste Andre Dumas (1800-1884) (none 1823, Geneva)
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+Josiah Parsons Cooke (1827-1894) (AB 1848, Harvard)
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+Charles Loring Jackson (1847-1935) (MA 1871, Harvard)
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+Henry Augustus Torrey (1871-1910) (PhD 1897, Harvard)
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+Roger Adams (1889-1971) (PhD 1912, Harvard)
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+Samuel Marion McElvain (1897-1973) (PhD – BioChem 1923, Illinois)
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+Gilbert J Stork (1921-____) (PhD 1946, Wisconsin)
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+Timothy Lee MacDonald (____-____) (PhD 1975, Columbia)
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+Jetze J Tepe (1968-____) (PhD 1998, Virginia) (MSU 2000-____)

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+Rahman Shah Zaib Saleem (____-____) (PhD 2011, MSU) (LUMS 2012-____)

Title Publication Author Year
Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells Iranian Journal of Science and Technology, Transaction A: Science Batool S., Ullah S., Tabassum S., Bilal A., Faisal A., Saleem R.S.Z., Ahmad M.S. 2019
Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance Bioorganic Chemistry Riaz S., Iqbal M., Ullah R., Zahra R., Chotana G.A., Faisal A., Saleem R.S.Z. 2019
Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation Bioorganic Chemistry Farrukh S.U.B., Javed I., Ather A.Q., Emwas A.-H., Alazmi M., Gao X., Chotana G.A., Davis T.P., Ke P.C., Saleem R.S.Z. 2019
A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-Aminoimidazolone Derivatives ChemistrySelect Hanif A., Sardar A., Alazmi M., Tariq H., Emwas A.-H., Gao X., Chotana G.A., Zaib Saleem R.S. 2019
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance Scientific Reports Manzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A. 2018
Synthesis, in vitro and in silico studies of S-alkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as cholinesterase inhibitors Pakistan journal of pharmaceutical sciences Arfan M., Siddiqui S.Z., Abbasi M.A., Rehman A., Shah S.A.A., Ashraf M., Rehman J., Saleem R.S.Z., Khalid H., Hussain R., Khan U. 2018
Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls Synthesis (Germany) Asghar S., Shahzadi T., Alazmi M., Gao X., Emwas A.-H., Saleem R.S.Z., Batool F., Chotana G.A. 2018
Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) Scientific reports Manzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A. 2018
Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation Synthesis (Germany) Shahzadi T., Saleem R.S.Z., Chotana G.A. 2018
The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activity Current Organic Synthesis Rendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M. 2017
Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grass Journal of Microbiology and Biotechnology Shahid I., Rizwan M., Baig D.N., Saleem R.S., Malik K.A., Mehnaz S. 2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agents Bioorganic and Medicinal Chemistry Letters Iftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z. 2017
Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel Journal of Materials Chemistry B Sohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G. 2016
A concise total synthesis of hymenialdisine Tetrahedron Letters Saleem R.S.Z., J. Tepe J. 2015
Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2 Journal of Natural Products Mehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G. 2013
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors Bioorganic and Medicinal Chemistry Saleem R.S.Z., Lansdell T.A., Tepe J.J. 2012
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors ACS Chemical Biology Nguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J. 2012
Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones Journal of Organic Chemistry Saleem R.S.Z., Tepe J.J. 2010
5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid Acta Crystallographica Section E: Structure Reports Online Zia-Ur-Rehman M., Elsegood M.R.J., Akbar N., Shah Zaib Saleem R. 2008