Faculty Profile

Dr. Rahman Shah Zaib Saleem

Assistant Professor

Department Of Chemistry & Chemical Engineering

Dr. Rahman Shah Zaib Saleem is employing organic chemistry tools in designing the drugs of the future and in materials. He joined LUMS in 2012 as an assistant professor. He has been interested in the development of organic methodology as well as the synthesis of the compound libraries to modulate various cellular proteins involved in the cell cycle (notably kinases, centrosome clustering, Phosphohistonase 3P, MDM2-p53, tubulin, hIAPP). On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) as well as the modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of the natural products.

Post-doctoral/Work experience

2012- to date     Assitant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS

Summer 2016    DAAD fellow, University of Saarland, Germany

Summer 2014    Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK

Summer 2012    Post-Doctoral Research Visit, University of Bristol, UK

Education

2011      PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)

2004      MPhil, GC University, Lahore, Pakistan

2002      MSc, GC University, Lahore, Pakistan (First position in the university)

2000      BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan

Roll of Honors

Academic roll of honor (2002)

Awards

2016                     DAAD Research Stays for University Academics and Scientists, University of Saarland

2013-14                Herchel Smith fellowship, University of Cambridge

2012                     LUMS’ SSE Deans travel award for the summer research visit to University of Bristol

2006-11                Fulbright PhD fellowship

2011                     Dissertation completion fellowship

2011                     Graduation school travel fellowship, Michigan State University

2006                     Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University

2006                     XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium

2003                     Orient Dr. Ata-ur-Rehman chemistry award and gold medal

2002                     Academic excellence award, GC University Lahore

2002                     Prof. Abdul Rashid Tariq gold medal

1998                     President talent farming award

1996                     Jamiat gold medal

Chemical Geneology

Guillaume Francois Rouelle (1703-1770) (Apothecary 1725, Paris)
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+Antoine Laurent Lavoisier (1743-1794) (LLB 1764, Paris)
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+Jean Baptiste Michel Bucquet (1746-1780) (MD 1770, Paris)
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+Antoine Francois de Fourcroy (1755-1809) (MD 1780, Paris)
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+Louis Nicolas Vauquelin (1763-1829) (MA 1790, Paris)
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+Louis Jacques Thenard (1777-1857) (MA 1797, Paris)
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+Jean Baptiste Andre Dumas (1800-1884) (none 1823, Geneva)
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+Josiah Parsons Cooke (1827-1894) (AB 1848, Harvard)
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+Charles Loring Jackson (1847-1935) (MA 1871, Harvard)
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+Henry Augustus Torrey (1871-1910) (PhD 1897, Harvard)
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+Roger Adams (1889-1971) (PhD 1912, Harvard)
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+Samuel Marion McElvain (1897-1973) (PhD – BioChem 1923, Illinois)
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+Gilbert J Stork (1921-____) (PhD 1946, Wisconsin)
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+Timothy Lee MacDonald (____-____) (PhD 1975, Columbia)
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+Jetze J Tepe (1968-____) (PhD 1998, Virginia) (MSU 2000-____)

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+Rahman Shah Zaib Saleem (____-____) (PhD 2011, MSU) (LUMS 2012-____)

TitlePublicationAuthorYear
Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistanceBioorganic ChemistryRiaz S., Iqbal M., Ullah R., Zahra R., Chotana G.A., Faisal A., Saleem R.S.Z.2019
Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregationBioorganic ChemistryFarrukh S.U.B., Javed I., Ather A.Q., Emwas A.-H., Alazmi M., Gao X., Chotana G.A., Davis T.P., Ke P.C., Saleem R.S.Z.2019
A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-Aminoimidazolone DerivativesChemistrySelectHanif A., Sardar A., Alazmi M., Tariq H., Emwas A.-H., Gao X., Chotana G.A., Zaib Saleem R.S.2019
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistanceScientific ReportsManzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A.2018
Synthesis, in vitro and in silico studies of S-alkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as cholinesterase inhibitorsPakistan journal of pharmaceutical sciencesArfan M., Siddiqui S.Z., Abbasi M.A., Rehman A., Shah S.A.A., Ashraf M., Rehman J., Saleem R.S.Z., Khalid H., Hussain R., Khan U.2018
Iridium-Catalyzed Regioselective Borylation of Substituted BiarylsSynthesis (Germany)Asghar S., Shahzadi T., Alazmi M., Gao X., Emwas A.-H., Saleem R.S.Z., Batool F., Chotana G.A.2018
Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and OxidationSynthesis (Germany)Shahzadi T., Saleem R.S.Z., Chotana G.A.2018
The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activityCurrent Organic SynthesisRendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M.2017
Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grassJournal of Microbiology and BiotechnologyShahid I., Rizwan M., Baig D.N., Saleem R.S., Malik K.A., Mehnaz S.2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agentsBioorganic and Medicinal Chemistry LettersIftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z.2017
Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxelJournal of Materials Chemistry BSohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G.2016
A concise total synthesis of hymenialdisineTetrahedron LettersSaleem R.S.Z., J. Tepe J.2015
Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2Journal of Natural ProductsMehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G.2013
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitorsBioorganic and Medicinal ChemistrySaleem R.S.Z., Lansdell T.A., Tepe J.J.2012
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitorsACS Chemical BiologyNguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J.2012
Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolonesJournal of Organic ChemistrySaleem R.S.Z., Tepe J.J.2010
5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acidActa Crystallographica Section E: Structure Reports OnlineZia-Ur-Rehman M., Elsegood M.R.J., Akbar N., Shah Zaib Saleem R.2008