Research group page: OrgChem.lums.edu.pk
Google Scholar: https://scholar.google.com.pk/citations?hl=en&user=dGv6WBMAAAAJ&view_op=list_works&sortby=pubdate
LinkedIn: https://www.linkedin.com/in/rahman-shah-zaib-saleem-b0984734/
Twitter: https://twitter.com/RahmanSZSaleem
Facebook: https://www.facebook.com/rahman.saleem/
Bio:
Dr. Rahman Shah Zaib Saleem joined LUMS in 2012 as an assistant professor and was tenured and promoted to associate professor in 2020. He is an enthusiastic experienced organic chemist with a proven track record in medicinal chemistry and materials. He enjoys teaching and training organic chemistry, spectroscopy, medicinal chemistry and drug discovery courses to undergraduate and postgraduate students. He builds effective collaborations within and outside of the institution.
In medicinal chemistry, he has expertise in the discovery of lead molecules for various cellular targets. His specialties include hit and lead generation, lead optimization, medicinal chemistry, organic synthesis and methodology, structure-based drug design, data analysis, natural product isolation and structure elucidation.
On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) and modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of natural products.
Post-doctoral/Work experience
Jan 2020- to date Associate Professor (tenure), Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Jan 2012- Jan 2020 Assistant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2019 DAAD fellow, University of Saarland, Germany
Summer 2016 DAAD fellow, University of Saarland, Germany
Summer 2014 Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012 Post-Doctoral Research Visit, University of Bristol, UK
Education
2011 PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004 MPhil, GC University, Lahore, Pakistan
2002 MSc, GC University, Lahore, Pakistan (First position in the university)
2000 BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan
Roll of Honors
Academic roll of honor (2002)
Awards
2019 DAAD Research Stays for University Academics and Scientists, University of Saarland
2016 DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14 Herchel Smith fellowship, University of Cambridge
2012 LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11 Fulbright PhD fellowship
2011 Dissertation completion fellowship
2011 Graduation school travel fellowship, Michigan State University
2006 Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006 XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003 Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002 Academic excellence award, GC University Lahore
2002 Prof. Abdul Rashid Tariq gold medal
1998 President talent farming award
1996 Jamiat gold medal
| Title | Publication | Author | Year |
|---|---|---|---|
| Synthesis, photophysical, voltammetric, and DFT studies of 4-aminochalones | Journal of Photochemistry and Photobiology A: Chemistry | 2023 | |
| Potent heteroaromatic hydrazone based 1,2,4-triazine motifs: synthesis, anti-oxidant activity, cholinesterase inhibition, quantum chemical and molecular docking studies | Journal of Molecular Structure | 2023 | |
| Perplexing Polyphenolics: The Isolations, Syntheses, Reappraisals, and Bioactivities of Flavonoids, Isoflavonoids, and Neoflavonoids from 2016 to 2022 | Life | 2023 | |
| Centrosome Clustering & Chemotherapy | Mini-Reviews in Medicinal Chemistry | 2023 | |
| Selenium-containing Peptides and their Biological Applications | Current Medicinal Chemistry | 2022 | |
| Synthesis and Characterization of Griseofulvin Derivatives as Microtubule-Stabilizing Agents | ChemistrySelect | 2022 | |
| Indole-Containing Natural Products 2019???2022: Isolations, Reappraisals, Syntheses, and Biological Activities | Molecules | 2022 | |
| Synthesis, photophysical, electrochemical and computational studies of novel 2-aminoimidazolones with D-??-A framework | Journal of Photochemistry and Photobiology A: Chemistry | 2022 | |
| Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors | Journal of Natural Products | 2022 | |
| Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity | Pharmaceutical Chemistry Journal | 2022 | |
| Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells | ChemistrySelect | 2022 | |
| Iridium-Catalyzed C-H Borylation of CF<inf>3</inf>-Substituted Pyridines | ACS Omega | 2022 | |
| Synthesis and evaluation of novel 1, 2, 4-substituted triazoles for urease and anti-proliferative activity | Pakistan Journal of Pharmaceutical Sciences | 2022 | |
| Synthesis, Spectral Evaluation and in Silico Studies of S-Aralkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols: As suitable Alzheimer's disease drug candidates | Journal of the Chemical Society of Pakistan | 2021 | |
| Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel acetylcholinesterase and butyrylcholinesterase inhibitors | Journal of Molecular Structure | 2021 | |
| Structure Dependent Differential Modulation of A?? Fibrillization by Selenadiazole-Based Inhibitors | ACS Chemical Neuroscience | 2021 | |
| CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells | British Journal of Cancer | 2021 | |
| In Silico Validation, Fabrication and Evaluation of Nano-Liposomes of Bistorta amplexicaulis Extract for Improved Anticancer Activity Against Hepatoma Cell Line (HepG2) | Current Drug Delivery | 2021 | |
| Detection of aflatoxin M1 by fiber cavity attenuated phase shift spectroscopy | Optics Express | 2021 | |
| Plants as a promising reservoir of tyrosinase inhibitors | Mini-Reviews in Organic Chemistry | 2021 | |
| A comprehensive review of aminochalcones | Molecules | 2020 | |
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors | Journal of Natural Products | 2020 | |
| Recent advances in synthesis of organometallic complexes of indium | Reviews in Inorganic Chemistry | 2020 | |
| Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study | ChemistrySelect | 2020 | |
| Facile synthesis of NH-free 5-(hetero)aryl-pyrrole-2-carboxylates by catalytic C-H borylation and suzuki coupling | Molecules | 2020 |