Faculty Profile

Dr. Rahman Shah Zaib Saleem

Assistant Professor

Department Of Chemistry

Dr. Saleem is employing the skills of organic synthesis in designing drugs of the future and in developing organic dyes for light harvestation by solar cells. He joined LUMS in 2012 and since then he has been actively applying his organic synthesis to various applications that include developing The Drug Discovery Labs at LUMS. He is interested in the synthesis of the libraries of novel molecules that could modulate various cellular proteins involved in the cell cycle (notably kinases (Aurora kinases), centrosome clustering, Phosphohistonase 3P, MDM2-p53, AAA+ ATPase & 12-TM), development of new methodologies to access novel scafolds, novel ligands for nanoparticle and the isolation, characterization & synthesis of the natural products of biological importance and food & toxicology. He is also interested in the organic dyes for dye-sensitized solar cells. 

Dr. Saleem is keen to explore the collaborative endeavors across the universities to advance the scientific output and is always willing to help the students. He also takes care of the chromatographic facility (LC-MS) at LUMS.

Earlier, Dr. Rahman Saleem obtained his M.Sc. in Chemistry from GC University, Lahore, Pakistan with distinction (Gold Medal and Academic Role of Honor) in 2002 and MPhil in Chemistry in 2004. He served in GC University, Lahore for an academic year and then in Gujranwala Institute of Future Technologies as lecturer for three years. During this time he was awarded Orient Dr. Ata-ur-Rehman Chemistry Award & XIVth Star Award and was selected to present Pakistan in the 56th Meeting with Nobel Laureates in Lindau, Germany. In 2006, he obtained Fulbright scholarship for PhD studies at Michigan State University, USA. There, he worked, in the labs of Prof. Dr. Jetze Tepe, at the interface of chemistry and biology and focused on various research projects aimed towards cancer research. During his PhD, Dr. Saleem synthesized natural products and their analogs aimed at inhibiting check point kinase 2 and imidazoline based inhibitors of NF-κB pathway to study their binding interaction with proteasome 26s, developed the methodology for the synthesis of 1,2,4-triazoline and 1,2,4-triazoles via [2+3]-cycloaddition reactions of oxazolones and prepared photoaffinity labelled molecules to study the drug protein interaction. He completed his PhD in Chemistry in 2011 and returned to Pakistan. In the summer of 2012, he visited University of Bristol as visiting faculty and in 2014, he visited University of Cambridge as Herchel Smith fellow. Dr. Saleem, during his time in LUMS, has completed two research projects. He has presented his research work in various international and national conferences including the US National Organic Symposium.

    • Article
      • Saleem, R. S. Z. .(1999). Synthesis of 1, 2, 4-triazolines and triazoles utilizing oxazolones . ,
      • Saleem, R. S. Z. .(1999). Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors . ,
      • Saleem, R. S. Z. .(1999). Radioprotection by Hymenialdisine-Derived Checkpoint Kinase 2 Inhibitors . ,
      • Saleem, R. S. Z. .(1999). Lahorenoic Acids A-C, ortho-Dialkyl-Substituted Aromatic Acids from the Biocontrol Strain Pseudomonas aurantiaca PB-St2 . ,
      • Saleem, R. S. Z. .(1999). 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid . ,
      • Saleem, R. S. Z. .(1999). Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel . ,
      • Saleem, R. S. Z. .(1999). Heterocyclic Interconversion of Oxazolones into Triazolinesand Triazoles . ,
    • Journal Articles
      • Saleem, R. S. Z. .(2014). A concise total synthesis of hymenialdisine . Tetrahedron Letters , Elsevier
    • Conference Papers
      • Saleem, R. S. Z. Efficient Synthesis Of Marine Alkaloid: Hymenialdisine- A Potential Lead In The Drug Discovery . International Conference on Emerging Trends in Life Sciences for Sustainable Development , Forman Christian College (A Chartered University)
      • Saleem, R. S. Z. Debromohymenialdine analogs- A SAR study for ChK2 vs ChK1 selectivity . Chemical Trends 2014- A conference on the recent trends in chemical research , Lahore University of Management Sciences
    • Research Paper
      • Saleem, R. S. Z. Isolation and Characterization of secondary metabolites produced by rhizobacteria and their potential as biocontrol agents . Grant of about PKR 9M submitted to HEC as Co-PI Status: Approved ,
Chemistry of the Organic Functional GroupsFall Semester 2014-151401
Organic Chemistry Lab IIFall Semester 2014-151401
Senior Project IFall Semester 2014-151401
Chemical Problems & ReportsFall Semester 2014-151401
Doctoral Thesis ResearchFall Semester 2014-151401
Master's Thesis IFall Semester 2014-151401
Advanced Organic ChemistrySpring Semester 2014-151402
Senior Project IISpring Semester 2014-151402
Directed Research ProjectSpring Semester 2014-151402
Chemistry Literature SeminarSpring Semester 2014-151402
Doctoral Thesis ResearchSpring Semester 2014-151402
Master's Thesis IISpring Semester 2014-151402
Chemistry of the Organic Functional GroupsFall Semester 2015-161501
Organic Chemistry Lab IIFall Semester 2015-161501
Senior Project IFall Semester 2015-161501
Chemistry SeminarFall Semester 2015-161501
Master's Thesis IFall Semester 2015-161501
Senior Project IISpring Semester 2015-161502
Chemical Problems & ReportsSpring Semester 2015-161502
Organic SpectroscopySpring Semester 2015-161502
Directed Research ProjectSpring Semester 2015-161502
Master's Thesis IISpring Semester 2015-161502
Doctoral Thesis ResearchSummer Semester 2015-161503
Chemistry of the Organic Functional GroupsFall Semester 2016-171601
Organic Chemistry Lab IIFall Semester 2016-171601
Senior Project IFall Semester 2016-171601
Chemistry Literature SeminarFall Semester 2016-171601
Doctoral Thesis ResearchFall Semester 2016-171601
Master's Thesis IFall Semester 2016-171601
Senior Project IISpring Semester 2016-171602
Organic SpectroscopySpring Semester 2016-171602
Chemistry Literature SeminarSpring Semester 2016-171602
Doctoral Thesis ResearchSpring Semester 2016-171602
Master's Thesis IISpring Semester 2016-171602
Doctoral Thesis ResearchSummer Semester 2016-171603
  • Past Courses
    Advanced Organic ChemistrySpring Semester 2011-121102
    Organic Chemistry Lab IIFall Semester 2012-131201
    Senior Project IFall Semester 2012-131201
    Introduction to Drug Discovery and DevelopmentFall Semester 2012-131201
    Spectroscopy - Theory & ApplicationsSpring Semester 2012-131202
    Advanced Organic ChemistrySpring Semester 2012-131202
    Senior Project IISpring Semester 2012-131202
    Organic Chemistry Lab IIFall Semester 2013-141301
    Senior Project IFall Semester 2013-141301
    Chemical Problems & ReportsFall Semester 2013-141301
    Advanced Organic ChemistrySpring Semester 2013-141302
    Independent StudySpring Semester 2013-141302
    Senior Project IISpring Semester 2013-141302
    RetrosynthesisSpring Semester 2013-141302
    Chemistry SeminarSpring Semester 2013-141302
    Organic SynthesisSpring Semester 2013-141302
    Directed Research ProjectSpring Semester 2013-141302
    Doctoral Thesis ResearchSummer Semester 2013-141303