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Dr. Rahman Shah Zaib Saleem
Associate Professor
Syed Babar Ali School of Science and Engineering
rahman.saleem@lums.edu.pk
  • Profile
  • Conferences, Publications and Journal Articles

Dr. Saleem joined LUMS in 2012 as an assistant professor and was tenured and promoted to associate professor in 2020.  He is an enthusiastic experienced organic chemist with a proven track record in the medicinal chemistry and materials. He enjoys teaching and training organic chemistry, spectroscopy, medicinal chemistry and drug discovery courses at undergraduate and postgraduate level. He builds effective collaborations within and outside of the institution.
In the medicinal chemistry, he has expertise in the discovery of lead molecules for various cellular targets. His specialties include hit and lead generation, lead optimization, medicinal chemistry, organic synthesis and methodology, structure-based drug design, data analysis, natural product isolation and structure elucidation.
On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) and modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of the natural products.

Post-doctoral/Work experience
Jan 2020- to date     Associate Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Jan 2012- Jan 2020     Assistant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2019    DAAD fellow, University of Saarland, Germany
Summer 2016    DAAD fellow, University of Saarland, Germany
Summer 2014    Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012    Post-Doctoral Research Visit, University of Bristol, UK
Education
2011      PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004      MPhil, GC University, Lahore, Pakistan
2002      MSc, GC University, Lahore, Pakistan (First position in the university)
2000      BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan
Roll of Honors
Academic roll of honor (2002)
Awards
2019                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2016                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14                Herchel Smith fellowship, University of Cambridge
2012                     LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11                Fulbright PhD fellowship
2011                     Dissertation completion fellowship
2011                     Graduation school travel fellowship, Michigan State University
2006                     Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006                     XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003                     Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002                     Academic excellence award, GC University Lahore
2002                     Prof. Abdul Rashid Tariq gold medal
1998                     President talent farming award
1996                     Jamiat gold medal

Research group page: OrgChem.lums.edu.pk

Title Publication Author Year
Detection of aflatoxin M1 by fiber cavity attenuated phase shift spectroscopy Optics Express 2021
A comprehensive review of aminochalcones Molecules 2020
Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors Journal of Natural Products 2020
Recent advances in synthesis of organometallic complexes of indium Reviews in Inorganic Chemistry 2020
Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study ChemistrySelect 2020
A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)mediated multidrug resistance PLoS ONE 2020
Facile synthesis of NH-free 5-(hetero)aryl-pyrrole-2-carboxylates by catalytic C-H borylation and suzuki coupling Molecules 2020
Biosynthesis of zno nanoparticles using ocimum basilicum and determination of its antimicrobial activity Journal of Animal and Plant Sciences 2020
Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells Iranian Journal of Science and Technology, Transaction A: Science 2019
Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance Bioorganic Chemistry 2019
Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation Bioorganic Chemistry 2019
A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-Aminoimidazolone Derivatives ChemistrySelect 2019
Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity Pakistan Journal of Pharmaceutical Sciences 2019
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance Scientific Reports 2018
Synthesis, in vitro and in silico studies of S-alkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as cholinesterase inhibitors Pakistan journal of pharmaceutical sciences 2018
Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls Synthesis (Germany) 2018
Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) Scientific reports 2018
Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation Synthesis (Germany) 2018
The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activity Current Organic Synthesis 2017
Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grass Journal of Microbiology and Biotechnology 2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agents Bioorganic and Medicinal Chemistry Letters 2017
Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel Journal of Materials Chemistry B 2016
A concise total synthesis of hymenialdisine Tetrahedron Letters 2015
Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2 Journal of Natural Products 2013
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors Bioorganic and Medicinal Chemistry 2012

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