Dr. Amir Faisal received his PhD in Cell Biology from Friedrich Miescher Institute for Biomedical Research/University of Basel, Switzerland in 2004. During his PhD he identified novel roles for Shc protein, an important adaptor downstream of tyrosine kinases, in insulin signalling and cytoskeletal reorganization. He received his first postdoctoral training (2004-2008) in Protein Phosphorylation Laboratory at London Research Institute where he discovered that another adaptor protein, MyD88, couples Protein Kinase C epsilon to Toll like receptors during innate immunity. From 2008 to 2014, he worked at Cancer Therapeutics Unit of Institute of Cancer Research in Sutton first as postdoctoral fellow and later as senior scientist. He played an important role in progression of several drug discovery projects, one of which resulted in discovery of a pre-clinical development candidate that will undergo phase I clinical trials in 2016. After joining LUMS in August 2014, he has been establishing a cancer therapeutics lab at SBASSE.
| Title | Publication | Author | Year |
|---|---|---|---|
| Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil | International Journal of Pharmaceutics | 2020 | |
| Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation | Stem Cell Research and Therapy | 2020 | |
| A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)mediated multidrug resistance | PLoS ONE | 2020 | |
| Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736 | Blood Advances | 2020 | |
| A facile and versatile route to functional poly(propylene) surfaces via UV-curable coatings | Reactive and Functional Polymers | 2019 | |
| Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species | European Journal of Pharmaceutical Sciences | 2019 | |
| Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells | Iranian Journal of Science and Technology, Transaction A: Science | 2019 | |
| Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance | Bioorganic Chemistry | 2019 | |
| Hydrothermal synthesis of carbon nanodots from bovine gelatin and PHM3 microalgae strain for anticancer and bioimaging applications | Nanoscale Advances | 2019 | |
| Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells | Cell Cycle | 2019 | |
| High proliferation rate and a compromised spindle assembly checkpoint confers sensitivity to the MPS1 inhibitor BOS172722 in triple-negative breast cancers | Molecular Cancer Therapeutics | 2019 | |
| Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance | Scientific Reports | 2018 | |
| ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming | Scientific Reports | 2018 | |
| Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722) | Journal of Medicinal Chemistry | 2018 | |
| CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin | Placenta | 2018 | |
| Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) | Scientific reports | 2018 | |
| Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis | Oncotarget | 2018 | |
| Nicotine exposure augments renal toxicity of 5-azacytidine through p66shc: Prevention by resveratrol | Anticancer Research | 2017 | |
| Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy | British Journal of Cancer | 2017 | |
| Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines | Natural Product Research | 2017 | |
| Synthesis and evaluation of modified chalcone based p53 stabilizing agents | Bioorganic and Medicinal Chemistry Letters | 2017 | |
| Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach | Journal of Medicinal Chemistry | 2016 | |
| 7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent | Bioorganic and Medicinal Chemistry Letters | 2015 | |
| Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug resistance | Cancer Research | 2015 | |
| Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines | Bioorganic and Medicinal Chemistry Letters | 2014 |