Faculty Profile

Dr. Amir Faisal

Associate Professor

Department Of Biology

Dr. Amir Faisal received his PhD in Cell Biology from Friedrich Miescher Institute for Biomedical Research/University of Basel, Switzerland in 2004. During his PhD he identified novel roles for Shc protein, an important adaptor downstream of tyrosine kinases, in insulin signalling and cytoskeletal reorganization. He received his first postdoctoral training (2004-2008) in Protein Phosphorylation Laboratory at London Research Institute where he discovered that another adaptor protein, MyD88, couples Protein Kinase C epsilon to Toll like receptors during innate immunity. From 2008 to 2014, he worked at Cancer Therapeutics Unit of Institute of Cancer Research in Sutton first as postdoctoral fellow and later as senior scientist. He played an important role in progression of several drug discovery projects, one of which resulted in discovery of a pre-clinical development candidate that will undergo phase I clinical trials in 2016. After joining LUMS in August 2014, he has been establishing a cancer therapeutics lab at SBASSE.

Journal Articles
- Article
  - Faisal, A. .(1999). Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA . ,
  - Faisal, A. .(1999). The regulated assembly of a PKCϵ complex controls the completion of cytokinesis . ,
  - Faisal, A. .(1999). p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells . ,
  - Faisal, A. .(1999). Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns . ,
  - Faisal, A. .(1999). Serine/threonine phosphorylation of shca regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling . ,
  - Faisal, A. .(1999). . ,
  - Faisal, A. .(1999). The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo . ,
  - Faisal, A. .(1999). Imidazo [4, 5-b] pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate . ,
  - Faisal, A. .(1999). p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury . ,
  - Faisal, A. .(1999). Protein kinases, from B to C . ,
  - Faisal, A. .(1999). A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2 . ,
  - Faisal, A. .(1999). Cisplatin induces apoptosis through the ERK-p66shc pathway in renal proximal tubule cells . ,
  - Faisal, A. .(1999). Structure-based design of orally bioavailable 1 H-pyrrolo [3, 2-c] pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1) . ,
  - Faisal, A. .(1999). Optimization of imidazo [4, 5-b] pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia . ,
  - Faisal, A. .(1999). Non-redundant role of Shc in Erk activation by cytoskeletal reorganization . ,
  - Faisal, A. .(1999). Aurora isoform selectivity: design and synthesis of imidazo [4, 5-b] pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells . ,
  - Faisal, A. .(1999). p66 Shc gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway . ,
  - Faisal, A. .(1999). Structure-based design of imidazo [1, 2-a] pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells . ,
  - Faisal, A. .(1999). Induction of uPA gene expression by the blockage of E-cadherin via Src-and Shc-dependent Erk signaling . ,
  - Faisal, A. .(1999). 7-(Pyrazol-4-yl)-3H-imidazo [4, 5-b] pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent . ,
  - Faisal, A. .(1999). Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance . ,
  - Faisal, A. .(1999). Targeting the PPM1D phenotype; 2, 4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines . ,
  - Faisal, A. .(1999). Abstract B74: The dual FLT3-Aurora inhibitor CCT241736 overcomes resistance to selective FLT3 inhibition driven by FLT3 ligand and FLT3 point mutations in acute myeloid leukemia. . ,
  - Faisal, A. .(1999). Dual inhibition of Aurora and FLT3 kinases by CCT137690: a novel treatment strategy against FLT3-ITD positive AML in vitro and in vivo . ,
  - Faisal, A. .(1999). Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines . ,
  - Faisal, A. .(1999). Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. . ,
  - Faisal, A. .(1999). Rapid Discovery of Pyrido [3, 4-d] pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach . ,
  - Faisal, A. .(1999). Structure enabled design of inhibitors of the mitotic kinase MPS1 . ,
  - Faisal, A. .(1999). Fused heterocyclic compounds and their use . ,
  - Faisal, A. .(1999). CCT271850, a novel, selective, highly potent and orally bioavailable Mps1 kinase inhibitor. . ,
  - Faisal, A. .(1999). Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor . ,
  - Faisal, A. .(1999). Resistance to Selective FLT3 Inhibitors, Driven by FLT3 Ligand and FLT3 Point Mutations, Can Be Overcome with the Dual FLT3-Aurora Kinase Inhibitor CCT241736 . ,
  - Faisal, A. .(1999). CCT137690, a dual inhibitor of Aurora and FLT3 kinases, sensitizes FLT3-ITD positive acute myeloid leukemia and overcomes resistance to selective FLT3-inhibition . ,
  - Faisal, A. .(1999). A novel imidazo [4, 5-b] pyridine Aurora kinase inhibitor with anti-leukemic activity . ,
  - Faisal, A. .(1999). p66SHC inhibits the pro-survival EGFR/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells . ,
  - Faisal, A. .(1999). PKC control of cell division . ,
  - Faisal, A. .(1999). Role of ShcA in Cell Signaling . ,
  - Faisal, A. .(1999). MECHANISMS OF SIGNAL TRANSDUCTION-Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-PEST binding and involvement in insulin signaling. . ,

Title	Semester	Code
Seminars in Biology	Fall Semester 2014-15	1401
Cell Signaling	Fall Semester 2014-15	1401
Independent Study	Spring Semester 2014-15	1402
Senior Project II	Spring Semester 2014-15	1402
Directed Research Project	Spring Semester 2014-15	1402
Cancer Biology	Spring Semester 2014-15	1402
Introductory Biology	Fall Semester 2015-16	1501
Cell Biology	Fall Semester 2015-16	1501
Senior Project I	Fall Semester 2015-16	1501
Fundamentals of Molecular Techniques	Fall Semester 2015-16	1501
Master's Thesis I	Fall Semester 2015-16	1501
Directed Research Project	Fall Semester 2015-16	1501
Cell Signaling	Fall Semester 2015-16	1501
Introductory Biology	Spring Semester 2015-16	1502
Senior Project II	Spring Semester 2015-16	1502
Master's Thesis I	Spring Semester 2015-16	1502
Directed Research Project	Spring Semester 2015-16	1502
Cell Signaling	Spring Semester 2015-16	1502
Master's Thesis II	Spring Semester 2015-16	1502
Directed Research Project	Spring Semester 2015-16	1502
Doctoral Thesis Research	Summer Semester 2015-16	1503
Methods in Cell and Molecular Biology	Fall Semester 2016-17	1601
Cell Biology	Fall Semester 2016-17	1601
Senior Project I	Fall Semester 2016-17	1601
Advanced Methods in Biology	Fall Semester 2016-17	1601
Master's Thesis I	Fall Semester 2016-17	1601
Master's Thesis II	Fall Semester 2016-17	1601
Master's Thesis I	Fall Semester 2016-17	1601
Doctoral Thesis Research	Fall Semester 2016-17	1601
Introductory Biology	Spring Semester 2016-17	1602
Senior Project II	Spring Semester 2016-17	1602
Master's Thesis I	Spring Semester 2016-17	1602
Directed Research Project	Spring Semester 2016-17	1602
Cell Signaling	Spring Semester 2016-17	1602
Master's Thesis II	Spring Semester 2016-17	1602
Cancer Biology	Spring Semester 2016-17	1602
Doctoral Thesis Research	Spring Semester 2016-17	1602
Topics in Cancer Biology	Spring Semester 2016-17	1602
Senior Project II	Summer Semester 2016-17	1603
Doctoral Thesis Research	Summer Semester 2016-17	1603
Methods in Cell and Molecular Biology	Fall Semester 2017-18	1701
Cell Biology	Fall Semester 2017-18	1701
Advanced Methods in Biology	Fall Semester 2017-18	1701

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Faculty Profile

Dr. Amir Faisal

Associate Professor

Department Of Biology

Faisal, A. .(1999). Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA . ,

Faisal, A. .(1999). The regulated assembly of a PKCϵ complex controls the completion of cytokinesis . ,

Faisal, A. .(1999). p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells . ,

Faisal, A. .(1999). Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns . ,

Faisal, A. .(1999). Serine/threonine phosphorylation of shca regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling . ,

Faisal, A. .(1999). . ,

Faisal, A. .(1999). The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo . ,

Faisal, A. .(1999). Imidazo [4, 5-b] pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate . ,

Faisal, A. .(1999). p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury . ,

Faisal, A. .(1999). Protein kinases, from B to C . ,

Faisal, A. .(1999). A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2 . ,

Faisal, A. .(1999). Cisplatin induces apoptosis through the ERK-p66shc pathway in renal proximal tubule cells . ,

Faisal, A. .(1999). Structure-based design of orally bioavailable 1 H-pyrrolo [3, 2-c] pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1) . ,

Faisal, A. .(1999). Optimization of imidazo [4, 5-b] pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia . ,

Faisal, A. .(1999). Non-redundant role of Shc in Erk activation by cytoskeletal reorganization . ,

Faisal, A. .(1999). Aurora isoform selectivity: design and synthesis of imidazo [4, 5-b] pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells . ,

Faisal, A. .(1999). p66 Shc gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway . ,

Faisal, A. .(1999). Structure-based design of imidazo [1, 2-a] pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells . ,

Faisal, A. .(1999). Induction of uPA gene expression by the blockage of E-cadherin via Src-and Shc-dependent Erk signaling . ,

Faisal, A. .(1999). 7-(Pyrazol-4-yl)-3H-imidazo [4, 5-b] pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent . ,

Faisal, A. .(1999). Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance . ,

Faisal, A. .(1999). Targeting the PPM1D phenotype; 2, 4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines . ,

Faisal, A. .(1999). Abstract B74: The dual FLT3-Aurora inhibitor CCT241736 overcomes resistance to selective FLT3 inhibition driven by FLT3 ligand and FLT3 point mutations in acute myeloid leukemia. . ,

Faisal, A. .(1999). Dual inhibition of Aurora and FLT3 kinases by CCT137690: a novel treatment strategy against FLT3-ITD positive AML in vitro and in vivo . ,

Faisal, A. .(1999). Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines . ,

Faisal, A. .(1999). Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. . ,

Faisal, A. .(1999). Rapid Discovery of Pyrido [3, 4-d] pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach . ,

Faisal, A. .(1999). Structure enabled design of inhibitors of the mitotic kinase MPS1 . ,

Faisal, A. .(1999). Fused heterocyclic compounds and their use . ,

Faisal, A. .(1999). CCT271850, a novel, selective, highly potent and orally bioavailable Mps1 kinase inhibitor. . ,

Faisal, A. .(1999). Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor . ,

Faisal, A. .(1999). Resistance to Selective FLT3 Inhibitors, Driven by FLT3 Ligand and FLT3 Point Mutations, Can Be Overcome with the Dual FLT3-Aurora Kinase Inhibitor CCT241736 . ,

Faisal, A. .(1999). CCT137690, a dual inhibitor of Aurora and FLT3 kinases, sensitizes FLT3-ITD positive acute myeloid leukemia and overcomes resistance to selective FLT3-inhibition . ,

Faisal, A. .(1999). A novel imidazo [4, 5-b] pyridine Aurora kinase inhibitor with anti-leukemic activity . ,

Faisal, A. .(1999). p66SHC inhibits the pro-survival EGFR/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells . ,

Faisal, A. .(1999). PKC control of cell division . ,

Faisal, A. .(1999). Role of ShcA in Cell Signaling . ,

Faisal, A. .(1999). MECHANISMS OF SIGNAL TRANSDUCTION-Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-PEST binding and involvement in insulin signaling. . ,