Dr. Amir Faisal
Associate Professor
Syed Babar Ali School of Science and Engineering
Dr. Amir Faisal received his PhD in Cell Biology from Friedrich Miescher Institute for Biomedical Research/University of Basel, Switzerland in 2004. During his PhD he identified novel roles for Shc protein, an important adaptor downstream of tyrosine kinases, in insulin signalling and cytoskeletal reorganization. He received his first postdoctoral training (2004-2008) in Protein Phosphorylation Laboratory at London Research Institute where he discovered that another adaptor protein, MyD88, couples Protein Kinase C epsilon to Toll like receptors during innate immunity. From 2008 to 2014, he worked at Cancer Therapeutics Unit of Institute of Cancer Research in Sutton first as postdoctoral fellow and later as senior scientist. He played an important role in progression of several drug discovery projects, one of which resulted in discovery of a pre-clinical development candidate that will undergo phase I clinical trials in 2016. After joining LUMS in August 2014, he has been establishing a cancer therapeutics lab at SBASSE.\
| Title | Publication | Author | Year |
|---|---|---|---|
| CanSeer: a translational methodology for developing personalized cancer models and therapeutics | Scientific Reports | Butt R.N., Amina B., Sultan M.U., Tanveer Z.B., Gondal M.N., Hussain R., Khan S., Akbar R., Nasir Z., Khalid M.F., Channan-Khan A.A., Faisal A., Shoaib M., Chaudhary S.U., | 2025 |
| Correction to: CanSeer: a translational methodology for developing personalized cancer models and therapeutics (Scientific Reports, (2025), 15, 1, (15080), 10.1038/s41598-025-99219-x) | Scientific Reports | Butt R.N., Amina B., Sultan M.U., Tanveer Z.B., Gondal M.N., Hussain R., Khan S., Akbar R., Nasir Z., Khalid M.F., Channan-Khan A.A., Faisal A., Shoaib M., Chaudhary S.U., | 2025 |
| Bicyclic 2-aminopyrimidine derivatives as potent VEGFR-2 inhibitors and apoptosis Inducers: Structure-Guided design, synthesis, anticancer assessment, and in-silico exploration | European Journal of Medicinal Chemistry | Siddique A., Shaheen S., Iftikhar A., Faisal A., Rehman H.M., Shah M., Tahir A., Rashid U., | 2025 |
| Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties | Plos One | Parveen S., Iqbal S., Maher S., Wilson P., Nasir H., Soomro S., Nisar S., Imran M., Riaz M., Urooj R., Bakhshi M.G., Essa M., Mukhtar F., Bhatti A., Janjua H.A., Faisal A., Saleem A., | 2025 |
| Computational identification and experimental characterization of an aurora kinase inhibitor | Bioorganic and Medicinal Chemistry | Muddassar M., Furqan M., Yousaf N., Khalid M.S., Mahmood N., Dar S., Fozail S., Saleem R.S.Z., ul Hussan S.S., Faisal A., | 2025 |
| Synthesis, mechanistic insights, and anticancer evaluation of novel 2-aroylbenzo[b]thiophen-3-ols: A DFT and Hirshfeld surface analysis | Journal of Molecular Structure | Mukhtar A., Iftikhar A., Maqbool M., Faisal A., Ayub K., Yousuf S., Saeed M., | 2025 |
| Integration of RNAi and Small Molecule Library Screens to Identify Targets for Drug Discovery | Methods in Molecular Biology | Drosopoulos K., Faisal A., Linardopoulos S., | 2025 |
| Targeting carbonic anhydrases II/IX/XII with novel series of coumarin-based compounds: Synthesis, biological activity and molecular dynamics analysis | Journal of Molecular Structure | Takla F.N., Zaib S., Bayoumi W.A., Shehzadi K., El-Messery S.M., Anjum S., Faisal A., Nasr M.N.A., | 2024 |
| Synthesis and characterization of bis-amide SSE1917 as a microtubule-stabilizing anticancer agent | Bioorganic Chemistry | Iqbal S., Firdous F., Furqan M., Bilal A., Fozail S., Pohl S.O.-G., Doleschall N.J., Myant K.B., Singh U., Emwas A.-H., Jaremko M., Faisal A., Saleem R.S.Z., | 2024 |
| Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor ?? degrader in breast cancer cells | Frontiers in Chemistry | Arif M.N., Sarwar S., Firdous F., Saleem R.S.Z., Nadeem H., Alamro A.A., Alghamdi A.A., Alshammari A.H., Farooq O., Khan R.A., Faisal A., | 2024 |
| Repurposing of investigational cancer drugs: Early phase discovery of dengue virus NS2B/NS3 protease inhibitors | Archiv Der Pharmazie | Saleem H.N., Kousar S., Jiskani A.H., Sohail I., Faisal A., Saeed M., | 2023 |
| Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance | ACS Medicinal Chemistry Letters | Firdous F., Riaz S., Furqan M., Fozail S., Fatima K., Pohl S.O., Doleschall N.J., Myant K.B., Kahfi J., Emwas A.-H., Jaremko M., Chotana G.A., Saleem R.S.Z., Faisal A., | 2023 |
| Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy | Frontiers in Medicine | Farhan A., Hassan G., Ali S.H.L., Yousaf Z., Shafique K., Faisal A., Younis B.B., Mirza S., | 2023 |
| Chemical Synthesis of Selenium-containing Peptides | Mini Reviews in Medicinal Chemistry | Ahmed K., Chotana G.A., Faisal A., Saleem R.S.Z., | 2023 |
| Selenium-containing Peptides and their Biological Applications | Current Medicinal Chemistry | Ahmed K., Ashraf D., Chotana G.A., Faisal A., Khan K.M., Saleem R.S.Z., | 2022 |
| Synthesis and Characterization of Griseofulvin Derivatives as Microtubule-Stabilizing Agents | Chemistryselect | Firdous F., Ibrahim R., Furqan M., Khan H., Raza H., Singh U., Emwas A.-H., Jaremko M., Chotana G.A., Faisal A., Saleem R.S.Z., | 2022 |
| Combined 3D-QSAR, molecular docking and dynamics simulations studies to model and design TTK inhibitors | Frontiers in Chemistry | Ashraf N., Asari A., Yousaf N., Ahmad M., Ahmed M., Faisal A., Saleem M., Muddassar M., | 2022 |
| Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors | Journal of Natural Products | Furqan M., Fayyaz A., Firdous F., Raza H., Bilal A., Saleem R.S.Z., Shahzad-Ul-Hussan S., Wang D., Youssef F.S., Al Musayeib N.M., Ashour M.L., Hussain H., Faisal A., | 2022 |
| Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells | Chemistryselect | Farrukh U.B., Bilal A., Zahid H., Iqbal M., Manzoor S., Firdous F., Furqan M., Azeem M., Emwas A.-H., Alazmi M., Gao X., Saleem R.S.Z., Faisal A., | 2022 |
| Reduction-Sensitive Dextran-Paclitaxel Polymer-Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and in Vitro Anticancer Efficacy | Bioconjugate Chemistry | Kanwal S., Naveed M., Arshad A., Arshad A., Firdous F., Faisal A., Yameen B., | 2021 |
| Polycomb Requires Chaperonin Containing TCP-1 Subunit 7 for Maintaining Gene Silencing in Drosophila | Frontiers in Cell and Developmental Biology | Shaheen N., Akhtar J., Umer Z., Khan M.H.F., Bakhtiari M.H., Saleem M., Faisal A., Tariq M., | 2021 |
| CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells | British Journal of Cancer | Tariq M.U., Furqan M., Parveen H., Ullah R., Muddassar M., Saleem R.S.Z., Bavetsias V., Linardopoulos S., Faisal A., | 2021 |
| A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer | Frontiers in Oncology | Gondal M.N., Butt R.N., Shah O.S., Sultan M.U., Mustafa G., Nasir Z., Hussain R., Khawar H., Qazi R., Tariq M., Faisal A., Chaudhary S.U., | 2021 |
| Synthesis of diosgenin conjugated gold nanoparticles using algal extract of Dictyosphaerium sp. and in-vitro application of their antiproliferative activities | Materials Today Communications | Amina S.J., Iqbal M., Faisal A., Shoaib Z., Niazi M.B.K., Ahmad N.M., Khalid N., Janjua H.A., | 2021 |
| Glyceryl Monostearate Based Solid Lipid Nanoparticles for Controlled Delivery of Docetaxel | Current Drug Delivery | Rai N., Madni A., Faisal A., Jamshaid T., Khan M.I., Khan M.M., Parveen F., | 2021 |