Faculty Profile

Dr. Amir Faisal

Associate Professor

Department Of Biology

Dr. Amir Faisal received his PhD in Cell Biology from Friedrich Miescher Institute for Biomedical Research/University of Basel, Switzerland in 2004. During his PhD he identified novel roles for Shc protein, an important adaptor downstream of tyrosine kinases, in insulin signalling and cytoskeletal reorganization. He received his first postdoctoral training (2004-2008) in Protein Phosphorylation Laboratory at London Research Institute where he discovered that another adaptor protein, MyD88, couples Protein Kinase C epsilon to Toll like receptors during innate immunity. From 2008 to 2014, he worked at Cancer Therapeutics Unit of Institute of Cancer Research in Sutton first as postdoctoral fellow and later as senior scientist. He played an important role in progression of several drug discovery projects, one of which resulted in discovery of a pre-clinical development candidate that will undergo phase I clinical trials in 2016. After joining LUMS in August 2014, he has been establishing a cancer therapeutics lab at SBASSE.

ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and ReprogrammingScientific ReportsShah O.S., Chaudhary M.F.A., Awan H.A., Fatima F., Arshad Z., Amina B., Ahmed M., Hameed H., Furqan M., Khalid S., Faisal A., Chaudhary S.U.2018
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistanceScientific ReportsManzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A.2018
Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosisOncotargetGurden M.D., Anderhub S.J., Faisal A., Linardopoulos S.2018
Nicotine exposure augments renal toxicity of 5-azacytidine through p66shc: Prevention by resveratrolAnticancer ResearchArany I., Hall S., Faisal A., Dixit M.2017
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacyBritish Journal of CancerFaisal A., Mak G.W.Y., Gurden M.D., Xavier C.P.R., Anderhub S.J., Innocenti P., Westwood I.M., Naud S., Hayes A., Box G., Valenti M.R., De Haven Brandon A.K., O'Fee L., Schmitt J., Woodward H.L., Burke R., Vanmontfort R.L.M., Blagg J., Raynaud F.I., Eccles S.A., Hoelder S., Linardopoulos S.2017
Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell linesNatural Product ResearchRiaz M., Bilal A., Ali M.S., Fatima I., Faisal A., Sherkheli M.A., Asghar A.2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agentsBioorganic and Medicinal Chemistry LettersIftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z.2017
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization ApproachJournal of Medicinal ChemistryInnocenti P., Woodward H.L., Solanki S., Naud S., Westwood I.M., Cronin N., Hayes A., Roberts J., Henley A.T., Baker R., Faisal A., Mak G.W.-Y., Box G., Valenti M., De Haven Brandon A., O'Fee L., Saville H., Schmitt J., Matijssen B., Burke R., Van Montfort R.L.M., Raynaud F.I., Eccles S.A., Linardopoulos S., Blagg J., Hoelder S.2016
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituentBioorganic and Medicinal Chemistry LettersBavetsias V., Perez-Fuertes Y., McIntyre P.J., Atrash B., Kosmopoulou M., O'Fee L., Burke R., Sun C., Faisal A., Bush K., Avery S., Henley A., Raynaud F.I., Linardopoulos S., Bayliss R., Blagg J.2015
Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug resistanceCancer ResearchGurden M.D., Westwood I.M., Faisal A., Naud S., Cheung K.-M.J., McAndrew C., Wood A., Schmitt J., Boxall K., Mak G., Workman P., Burke R., Hoelder S., Blagg J., Van Montfort R.L.M., Linardopoulos S.2015
Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-linesBioorganic and Medicinal Chemistry LettersCheeseman M.D., Faisal A., Rayter S., Barbeau O.R., Kalusa A., Westlake M., Burke R., Swan M., Van Montfort R., Linardopoulos S., Jones K.2014
Structure-based design of orally bioavailable 1 h -Pyrrolo[3,2- C ]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)Journal of Medicinal ChemistryNaud S., Westwood I.M., Faisal A., Sheldrake P., Bavetsias V., Atrash B., Cheung K.-M.J., Liu M., Hayes A., Schmitt J., Wood A., Choi V., Boxall K., Mak G., Gurden M., Valenti M., De Haven Brandon A., Henley A., Baker R., McAndrew C., Matijssen B., Burke R., Hoelder S., Eccles S.A., Raynaud F.I., Linardopoulos S., Van Montfort R.L.M., Blagg J.2013
Aurora isoform selectivity: Design and synthesis of imidazo[4,5- B ]pyridine derivatives as highly selective inhibitors of aurora-A kinase in cellsJournal of Medicinal ChemistryBavetsias V., Faisal A., Crumpler S., Brown N., Kosmopoulou M., Joshi A., Atrash B., Perez-Fuertes Y., Schmitt J.A., Boxall K.J., Burke R., Sun C., Avery S., Bush K., Henley A., Raynaud F.I., Workman P., Bayliss R., Linardopoulos S., Blagg J.2013
Optimization of imidazo[4,5- b ]pyridine-based kinase inhibitors: Identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemiaJournal of Medicinal ChemistryBavetsias V., Crumpler S., Sun C., Avery S., Atrash B., Faisal A., Moore A.S., Kosmopoulou M., Brown N., Sheldrake P.W., Bush K., Henley A., Box G., Valenti M., De Haven Brandon A., Raynaud F.I., Workman P., Eccles S.A., Bayliss R., Linardopoulos S., Blagg J.2012
Selective FLT3 inhibition of FLT3-ITD+acute myeloid leukaemia resulting in secondary D835Y mutation: A model for emerging clinical resistance patternsLeukemiaMoore A.S., Faisal A., De Castro D.G., Bavetsias V., Sun C., Atrash B., Valenti M., De Haven Brandon A., Avery S., Mair D., Mirabella F., Swansbury J., Pearson A.D.J., Workman P., Blagg J., Raynaud F.I., Eccles S.A., Linardopoulos S.2012
The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in VivoMolecular Cancer TherapeuticsFaisal A., Vaughan L., Bavetsias V., Sun C., Atrash B., Avery S., Jamin Y., Robinson S.P., Workman P., Blagg J., Raynaud F.I., Eccles S.A., Chesler L., Linardopoulos S.2011
Cisplatin induces apoptosis through the ERK-p66shc pathway in renal proximal tubule cellsCancer LettersClark J.S., Faisal A., Baliga R., Nagamine Y., Arany I.2010
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cellsBioorganic and Medicinal Chemistry LettersBouloc N., Large J.M., Kosmopoulou M., Sun C., Faisal A., Matteucci M., Reynisson J., Brown N., Atrash B., Blagg J., McDonald E., Linardopoulos S., Bayliss R., Bavetsias V.2010
Imidazo[4,5-b]pyridine derivatives as inhibitors of aurora kinases: Lead optimization studies toward the identification of an orally bioavailable preclinical development candidateJournal of Medicinal ChemistryBavetsias V., Large J.M., Sun C., Bouloc N., Kosmopoulou M., Matteucci M., Wilsher N.E., Martins V., Reynisson J., Atrash B., Faisal A., Urban F., Valenti M., De Haven Brandon A., Box G., Raynaud F.I., Workman P., Eccles S.A., Bayliss R., Blagg J., Linardopoulos S., McDonald E.2010
p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injuryAmerican Journal of Physiology - Renal PhysiologyArany I., Faisal A., Clark J.S., Vera T., Baliga R., Nagamine Y.2010
A cancer-associated Aurora a mutant is mislocalized and misregulated due to loss of interaction with TPX2Journal of Biological ChemistryBibby R.A., Tang C., Faisal A., Drosopoulos K., Lubbe S., Houlston R., Bayliss R., Linardopoulos S.2009
The regulated assembly of a PKCe complex controls the completion of cytokinesisNature Cell BiologySaurin A.T., Durgan J., Cameron A.J., Faisal A., Marber M.S., Parker P.J.2008
The scaffold MyD88 acts to couple protein kinase C?? to toll-like receptorsJournal of Biological ChemistryFaisal A., Saurin A., Gregory B., Foxwell B., Parker P.J.2008
p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cellsJournal of Biological ChemistryArany I., Faisal A., Nagamine Y., Safirstein R.L.2008
Protein kinases, from B to CBiochemical Society TransactionsCameron A.J., De Rycker M., Calleja V., Alcor D., Kjaer S., Kostelecky B., Saurin A., Faisal A., Laguerre M., Hemmings B.A., McDonald N., Larijani B., Parker P.J.2007
Fall Semester 2018-19Master's Thesis1801
Fall Semester 2018-19Senior Project1801
Fall Semester 2018-19Doctoral Thesis Research1801
Fall Semester 2018-19Doctoral Thesis Research1801
Fall Semester 2018-19Advanced Methods in Biology1801
Fall Semester 2018-19Seminars in Biology1801
Fall Semester 2018-19Cell Biology1801
Fall Semester 2018-19Methods in Cell and Molecular Biology1801
Summer Semester 2017-18Doctoral Thesis Research1703
Spring Semester 2017-18Master's Thesis1702
Spring Semester 2017-18Senior Project1702
Spring Semester 2017-18Doctoral Thesis Research1702
Spring Semester 2017-18Cell Signaling1702
Spring Semester 2017-18Directed Research Project1702
Spring Semester 2017-18Introductory Biology1702
Fall Semester 2017-18Master's Thesis1701
Fall Semester 2017-18Senior Project1701
Fall Semester 2017-18Doctoral Thesis Research1701
Fall Semester 2017-18Doctoral Thesis Research1701
Fall Semester 2017-18Advanced Methods in Biology1701
Fall Semester 2017-18Cell Biology1701
Fall Semester 2017-18Methods in Cell and Molecular Biology1701
Summer Semester 2016-17Doctoral Thesis Research1603
Summer Semester 2016-17Senior Project II1603
Spring Semester 2016-17Topics in Cancer Biology1602
Spring Semester 2016-17Doctoral Thesis Research1602
Spring Semester 2016-17Cancer Biology1602
Spring Semester 2016-17Master's Thesis II1602
Spring Semester 2016-17Cell Signaling1602
Spring Semester 2016-17Directed Research Project1602
Spring Semester 2016-17Master's Thesis I1602
Spring Semester 2016-17Senior Project II1602
Spring Semester 2016-17Introductory Biology1602
Fall Semester 2016-17Doctoral Thesis Research1601
Fall Semester 2016-17Master's Thesis I1601
Fall Semester 2016-17Master's Thesis II1601
Fall Semester 2016-17Master's Thesis I1601
Fall Semester 2016-17Advanced Methods in Biology1601
Fall Semester 2016-17Senior Project I1601
Fall Semester 2016-17Cell Biology1601
Fall Semester 2016-17Methods in Cell and Molecular Biology1601
Summer Semester 2015-16Doctoral Thesis Research1503
Spring Semester 2015-16Directed Research Project1502
Spring Semester 2015-16Master's Thesis II1502
Spring Semester 2015-16Cell Signaling1502
Spring Semester 2015-16Directed Research Project1502
Spring Semester 2015-16Master's Thesis I1502
Spring Semester 2015-16Senior Project II1502
Spring Semester 2015-16Introductory Biology1502
Fall Semester 2015-16Cell Signaling1501
Fall Semester 2015-16Directed Research Project1501
Fall Semester 2015-16Master's Thesis I1501
Fall Semester 2015-16Fundamentals of Molecular Techniques1501
Fall Semester 2015-16Senior Project I1501
Fall Semester 2015-16Cell Biology1501
Fall Semester 2015-16Introductory Biology1501
Spring Semester 2014-15Cancer Biology1402
Spring Semester 2014-15Directed Research Project1402
Spring Semester 2014-15Senior Project II1402
Spring Semester 2014-15Independent Study1402
Fall Semester 2014-15Cell Signaling1401
Fall Semester 2014-15Seminars in Biology1401