Dr. Saeed received his M.Sc. in chemistry from the University of the Punjab, Lahore, Pakistan with distinction (Punjab University topper with Gold Medal) in 1996. Before his Ph.D. research, he served at Research Assistant/Research Officer at H.E.J. Research Institute of Chemistry, University of Karachi. During this time he was awarded DAAD fellowship to conduct PhD research at the University of Tübingen, Germany under the supervision of Prof. Dr. h.c.(mult.) Wolfgang Voelter.
In 1998, Dr. Saeed started his PhD research on the total synthesis of a,b-unsaturated d-lactone-containing natural products by using carbohydrate as chiral templates. In 2000, he was selected by the DAAD to represent its students in the 50th Annual Nobel Laureate Meeting at Lindau, Germany. By 2001, he was able to synthesize several natural products and their unnatural analogs, which earned him a PhD degree from the University of Tübingen in the span of less than three years.
From 2001 to 2009, Dr. Saeed conducted post-doctorate research in the area of chemical carcinogenesis and cancer biology, by investigating the metabolism of estrogens, formation of genotoxic metabolites and their reactions with DNA to induce cancer-specific mutations, and the initiation of cancer. In 2009, he joined Department of Chemistry of the University of Iowa as Research Scholar and visiting assistant professor. He has published more than 40 peer-reviewed articles in reputed international journals, such as Journal of Biological Chemistry,International Journal of Cancer, Free Radical Biology and Medicine, Chemical Research in Toxicology, and Tetrahedron Letters. He has presented his research in several National and International meetings and conferences.
Since Aug 2014, Dr. Saeed is working at the Department of Chemistry/SBASSE LUMS as an associate professor.
Click here to view Dr. Saeed's research group webpage.
|Erratum: Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells (PLoS ONE (2013) 8:1 DOI: 10.1371/annotation/8c8c0cae-7f2f-4f37-9807- 2d02b6c14db1)||PLoS ONE||2013|
|Effect of Tumour Necrosis Factor-Alpha on Estrogen Metabolic Pathways in Breast Cancer Cells||Journal of Cancer||2012|
|Mechanism of DNA depurination by carcinogens in relation to cancer initiation||IUBMB Life||2012|
|Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease||IUBMB Life||2011|
|Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol||Journal of Steroid Biochemistry and Molecular Biology||2011|
|The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk||Journal of Steroid Biochemistry and Molecular Biology||2011|
|Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells||Free Radical Biology and Medicine||2011|
|N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells||Free Radical Biology and Medicine||2010|
|Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease||Free Radical Biology and Medicine||2010|
|Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells||PLoS ONE||2009|
|Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation||Free Radical Biology and Medicine||2009|
|NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells||Journal of Steroid Biochemistry and Molecular Biology||2009|
|Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: The defining link to natural estrogens||International Journal of Cancer||2009|
|Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol||Free Radical Biology and Medicine||2008|
|Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells||Cancer Prevention Research||2008|
|Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation||Free Radical Biology and Medicine||2007|
|Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition||Journal of Steroid Biochemistry and Molecular Biology||2007|
|Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol||International Journal of Cancer||2007|
|Formation of depurinating N3adenine and N7guanine adducts after reaction of 1,2-naphthoquinone or enzyme-activated 1,2-dihydroxynaphthalene with DNA. Implications for the mechanism of tumor initiation by naphthalene||Chemico-Biological Interactions||2007|
|The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: Implications for tumor-initiating activity||Chemical Research in Toxicology||2006|
|Development of monoclonal antibodies to 4-hydroxyestrogen-2-N- acetylcysteine conjugates: Immunoaffinity and spectroscopic studies||Chemical Research in Toxicology||2005|
|Novel spiro-quinone formation from 3???-hydroxydiethylstilbestrol after oxidation with silver oxide||Tetrahedron Letters||2005|
|Synthesis of the catechols of natural and synthetic estrogens by using 2-iodoxybenzoic acid (IBX) as the oxidizing agent||Steroids||2005|
|Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3???,4???-quinone.: Implications for mutagenic activity||Steroids||2005|
|Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3???,4???-quinone or enzyme-activated 3???-hydroxyhexestrol: Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens||Steroids||2005|