Faculty Profile

Dr. Muhammad Saeed

Associate Professor

Department Of Chemistry

Dr. Saeed received his M.Sc. in chemistry from the University of the Punjab, Lahore, Pakistan with distinction (Punjab University topper with Gold Medal) in 1996. Before his Ph.D. research, he served at Research Assistant/Research Officer at H.E.J. Research Institute of Chemistry, University of Karachi. During this time he was awarded DAAD fellowship to conduct PhD research at the University of Tübingen, Germany under the supervision of Prof. Dr. h.c.(mult.) Wolfgang Voelter.

 

In 1998, Dr. Saeed started his PhD research on the total synthesis of a,b-unsaturated d-lactone-containing natural products by using carbohydrate as chiral templates. In 2000, he was selected by the DAAD to represent its students in the 50th Annual Nobel Laureate Meeting at Lindau, Germany. By 2001, he was able to synthesize several natural products and their unnatural analogs, which earned him a PhD degree from the University of Tübingen in the span of less than three years.

 

From 2001 to 2009, Dr. Saeed conducted post-doctorate research in the area of chemical carcinogenesis and cancer biology, by investigating the metabolism of estrogens, formation of genotoxic metabolites and their reactions with DNA to induce cancer-specific mutations, and the initiation of cancer. In 2009, he joined Department of Chemistry of the University of Iowa as Research Scholar and visiting assistant professor. He has published more than 40 peer-reviewed articles in reputed international journals, such as Journal of Biological Chemistry,International Journal of Cancer, Free Radical Biology and Medicine, Chemical Research in Toxicology, and Tetrahedron Letters. He has presented his research in several National and International meetings and conferences.

Since Aug 2014, Dr. Saeed is working at the Department of Chemistry/SBASSE LUMS as an associate professor.

 

Click here to view Dr. Saeed's research group webpage.

    • Article
      • Saeed, M. .(1999). A novel method for the synthesis of 4 (3H)-quinazolinones . ,
      • Saeed, M. .(1999). Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases . ,
      • Saeed, M. .(1999). The greater reactivity of estradiol-3, 4-quinone vs estradiol-2, 3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity . ,
      • Saeed, M. .(1999). Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells . ,
      • Saeed, M. .(1999). Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells: The effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition . ,
      • Saeed, M. .(1999). Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol . ,
      • Saeed, M. .(1999). Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives . ,
      • Saeed, M. .(1999). Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol . ,
      • Saeed, M. .(1999). Synthesis of the catechols of natural and synthetic estrogens by using 2-iodoxybenzoic acid (IBX) as the oxidizing agent . ,
      • Saeed, M. .(1999). Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation . ,
      • Saeed, M. .(1999). Formation of depurinating N3adenine and N7guanine adducts after reaction of 1, 2-naphthoquinone or enzyme-activated 1, 2-dihydroxynaphthalene with DNA: Implications for the mechanism of tumor initiation by naphthalene . ,
      • Saeed, M. .(1999). Total synthesis and anti-leishmanial activity of R-(-)-argentilactone . ,
      • Saeed, M. .(1999). Oligomeric stability of Rapana venosa hemocyanin (RvH) and its structural subunits . ,
      • Saeed, M. .(1999). The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk . ,
      • Saeed, M. .(1999). Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3, 4-quinone and hexestrol-3´, 4´-quinone.: Implications for mutagenic activity . ,
      • Saeed, M. .(1999). Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells . ,
      • Saeed, M. .(1999). Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: the defining link to natural estrogens . ,
      • Saeed, M. .(1999). Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3´, 4´-quinone or enzyme-activated 3´-hydroxyhexestrol: implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens . ,
      • Saeed, M. .(1999). Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease . ,
      • Saeed, M. .(1999). An expeditious approach to tri-substituted chiral thiazolines . ,
      • Saeed, M. .(1999). Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells . ,
      • Saeed, M. .(1999). A convenient method for the synthesis of cyclic trithiocarbonates on carbohydrate scaffolds . ,
      • Saeed, M. .(1999). NAD (P) H: quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells . ,
      • Saeed, M. .(1999). Development of monoclonal antibodies to 4-hydroxyestrogen-2-N-acetylcysteine conjugates: immunoaffinity and spectroscopic studies . ,
      • Saeed, M. .(1999). Syntheses of selected quaternary phenacylbromopyridinium compounds and their biological evaluation . ,
      • Saeed, M. .(1999). Synthesis and characterization of manganese oxide and investigation of its catalytic activities for oxidation of benzyl alcohol in liquid phase . ,
      • Saeed, M. .(1999). Antibiotics. Antiviral Drugs. Chemotherapeutics. Cytostatics-Syntheses and Cytotoxic, Antimicrobial, Antifungal and Cardiovascular Activity of New Quinoline Derivatives . ,
      • Saeed, M. .(1999). Syntheses, antibacterial, cytotoxic and antifungal effects of new 3-carboxy-1-phenacylpyridinium salts . ,
      • Saeed, M. .(1999). Syntheses and Evaluation of the Analgesic Activity of Some 4-Acetyl-4-phenylpiperidine and 4-Hydroxy-4-phenylpiperidine Derivatives . ,
      • Saeed, M. .(1999). Mechanism of tumor initiation by the human carcinogen diethylstilbestrol: the defining link to natural estrogens . ,
      • Saeed, M. .(1999). Total synthesis of S-(+)-argentilactone . ,
      • Saeed, M. .(1999). An Expeditious Synthesis of Optically Pure 1, 4, 5, 6-Tetrahydro-as-Triazines, Fused to the Carbohydrate Skeleton. . ,
      • Saeed, M. .(1999). Novel spiro-quinone formation from 3´-hydroxydiethylstilbestrol after oxidation with silver oxide . ,
      • Saeed, M. .(1999). New glycosides from Salvia moorcroftiana (Lamiaceae) . ,
      • Saeed, M. .(1999). A fast chemoenzymatic synthesis of [11 C]-N 5, N 10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells . ,
      • Saeed, M. .(1999). Breast cancer and prostate cancer assessment . ,
      • Saeed, M. .(1999). An efficient approach to the synthesis of tri-substituted iminothiazolidenes and their effects on the human neuroblastoma cell line . ,
      • Saeed, M. .(1999). The depurinating 4-hydroxyestrone (estradiol) 1-N3Ade DNA adducts as biomarkers of prostate cancer risk . ,
      • Saeed, M. .(1999). Formation of the DNA depurinating N3Ade and N7Gua adducts of 4-hydroxyestradiol by MCF-10F cells cultured with the carcinogenic estrogen metabolite 4-hydroxyestradiol . ,
      • Saeed, M. .(1999). Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3, 4-quinone and hexestrol-3´, 4´-quinone. Implications for metagenic activity . ,
      • Saeed, M. .(1999). Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3´, 4´-quinone or enzyme-activated 3´-hydroxyhexestrol. Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens . ,
      • Saeed, M. .(1999). Total Syntheses of R-(-)-Argentilactone, S-(+)-Argentilactone, R-(-)-Massoilactone,(5S, 6R)-O-Acetylosmundalactone as-Triazin-, Trithiocarbonate-and 4-(4-Substituted-1-piperazinyl) Derivatives from Sugar Templates . ,
      • Saeed, M. .(1999). Synthesis and properties of selected 4-substituted anhydro sugars . ,
      • Saeed, M. .(1999). Tumour Necrosis Factor-Alpha affects Estrogen Metabolic Pathways in Breast Cancer Cells . ,
    • Journal Articles
      • Saeed, M. .(2016). Synthesis of lignin model compound containing a beta-O-4 linkage . Zeitschrift fuer Naturforschung B-Chemical Sciences , De Gruyter
      • Saeed, M. .(2015). Targeting the de novo biosynthesis of thymidylate for the development of a PET probe for pancreatic cancer imaging . Biochemistry , American Chemical Society , pp. 1287-93
      • Saeed, M. .(2012). A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells . Nuclear Medicine and Biology , Elsevier , pp. 697-701
      • Saeed, M. .(2012). Mechanism of DNA depurination by carcinogens in relation to cancer initiation . IUBMB Life , Wiley , pp. 169-179
      • Saeed, M. .(2011). Formation of dopamine quinone-DNA adducts and their potential role in the aetiology of Parkinson's disease . IUBMB , Wiley , pp. 1087-93
      • Saeed, M. .(2011). Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol . Journal of Steroid Biochemistry and Molecular Biology , Elsevier , pp. 276-81
      • Saeed, M. .(2011). Novel positron emission tomography tracer distinguishes normal from cancerous cells . Journal of Biological Chemistry , Am Soc Biochem Mol Biol , pp. 33872-8
      • Saeed, M. .(2011). Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells . Free Radical Biology and Medicine , Elsevier , pp. 78-85
      • Saeed, M. .(2010). N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells . Free Radical Biology and Medicine , Elsevier , pp. 392-400
      • Saeed, M. .(2010). Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease . Free Radical Biology and Medicine , Elsevier , pp. 318-24
      • Saeed, M. .(2009). NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells . Journal of Steroid Biochemistry and Molecular Biology , Elsevier , pp. 56-66
      • Saeed, M. .(2009). Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation . Free Radical Biology and Medicine , Elsevier , pp. 1075-81
      • Saeed, M. .(2009). Mechanism of metabolic activation and DNA adduct formation by human carcinogen diethylstilbestrol: the defining link to natural estrogens . International Journal of Cancer , Wiely , pp. 1276-84
TitleSemesterCode
Selected Topics in Organic ChemistryFall Semester 2014-151401
Molecular SpectroscopySpring Semester 2014-151402
Organic SpectroscopySpring Semester 2014-151402
Directed Research ProjectSpring Semester 2014-151402
Chemistry Literature SeminarSpring Semester 2014-151402
Doctoral Thesis ResearchSummer Semester 2014-151403
Senior Project IFall Semester 2015-161501
Selected Topics in Organic ChemistryFall Semester 2015-161501
Doctoral Thesis ResearchFall Semester 2015-161501
Master's Thesis IFall Semester 2015-161501
Bio-organic ChemistryFall Semester 2015-161501
Advanced Organic ChemistrySpring Semester 2015-161502
Senior Project IISpring Semester 2015-161502
Chemical Problems & ReportsSpring Semester 2015-161502
Molecular SpectroscopySpring Semester 2015-161502
Doctoral Thesis ResearchSpring Semester 2015-161502
Master's Thesis IISpring Semester 2015-161502
Doctoral Thesis ResearchSummer Semester 2015-161503
Master's Thesis IFall Semester 2016-171601
Senior Project IFall Semester 2016-171601
Selected Topics in Organic ChemistryFall Semester 2016-171601
Doctoral Thesis ResearchFall Semester 2016-171601
Master's Thesis IFall Semester 2016-171601
Bio-organic ChemistryFall Semester 2016-171601
Advanced Organic ChemistrySpring Semester 2016-171602
Senior Project IISpring Semester 2016-171602
Molecular SpectroscopySpring Semester 2016-171602
Doctoral Thesis ResearchSpring Semester 2016-171602
Master's Thesis IISpring Semester 2016-171602
Doctoral Thesis ResearchSummer Semester 2016-171603