Transcriptional silencing by Polycomb group (PcG) proteins is a major paradigm for epigenetic inheritance from fly to human. The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to enforce gene silencing. However, the mechanisms underlying the inheritence of transcriptional silencing by different PRC complexes are unknown. Addressing this question has been extremely challenging due to technical limitations that do not discern the initiation from sequence-independent maintenance of repression.
July 28, 2020
Time:
9:00 pm
Online
Join us for this informative zoom session to learn how Dr. Oliver Bell addresses the concern by presenting an unexpected division of labor between different PRC1 and PRC2 complexes in epigenetic silencing.
Date: Tuesday, July 28, 2020
Time: 9:00 PM (PST)
The session will be moderated by Dr. Muhammad Tariq, Associate Professors, Syed Babar Ali School of Science and Engineering (SBASSE).
The colloquium will take place over Zoom and will be hosted on SBASSE’s Facebook page. You can access the page by clicking here.
Join us for an informative journey!
Speaker Profile
Dr. Oliver Bell
Dr. Bell is an Assistant Professor in the Dept. of Biochemistry and Molecular Medicine as well as the Dept. of Stem Cell and Regenerative Medicine at the Keck School of Medicine at the University of Southern California. His laboratory investigates the epigenetic mechanisms targeting chromatin modification to reinforce maintenance of gene expression states through genome replication. The Bell lab uses synthetic biology approaches, genetics and genomics to manipulate chromatin modifications and study their dynamics and inheritance. Ultimately, Dr. Bell’s research group aims to unravel the crosstalk between epigenetic regulation and cell plasticity.
