Farah Ashraf’s Inspiring Journey in Advancing Cancer Research
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We recently had the pleasure of speaking with Farah Ashraf, a PhD student at the Syed Babar Ali School of Science and Engineering (SBASSE), LUMS, currently visiting the Institute of Cancer Research (ICR) in London under the Higher Education Commission (HEC) International Research Support Initiative programme. Contributing to research on the anti-cancer properties of synthesised compounds and working on Chordoma-related projects, Farah's journey reflects a strong commitment to advancing cancer research and contributing to humanity. In our conversation, Farah shared insights into her academic journey, the challenges of cancer research, and her vision for the future.
How did your academic journey lead you to pursue cancer research?
I completed my BS in Chemistry from the University of Sargodha and then pursued an MPhil at Quaid-e-Azam University, Islamabad, in Biochemistry and Molecular Biology. While studying in Islamabad, I learned about LUMS and the excellent research opportunities it offers. Once I completed my MPhil, I was fortunate to be awarded a fully funded scholarship to continue my education at SBASSE, which has been a crucial step in advancing my career. In my third year, I was also awarded the SBARA (Syed Babar Ali Research Award) for my research project. It was at LUMS that I discovered my passion for cancer research, and this passion has only grown stronger.
How did you become involved with ICR, and what are you currently working on there?
Cancer has always been a cause I felt deeply passionate about, even though I was unable to pursue a medical career. It’s a global challenge with limited treatment options, and I wanted to contribute to something that could truly make a difference in people’s lives. This led me to focus on cancer research during my PhD, where I am studying the synthesised molecules developed by our research group—specifically, their anti-cancer properties, how these compounds act, and the mechanisms they follow.
Currently, I am working on a Chordoma project at ICR, which is particularly exciting and challenging. Chordoma is a rare and malignant tumour found in the spinal cord, making it difficult to treat due to its proximity to the central nervous system. One of the key molecular drivers of Chordoma is Brachyury, a transcription factor that is highly expressed in tumour cells but minimally present in healthy tissues. Given its crucial role in tumour progression and survival, Brachyury presents an excellent therapeutic target for combating Chordoma. Our research is centred on identifying and developing small-molecule inhibitors that can specifically target Brachyury, disrupt its expression, and ultimately hinder the progression of Chordoma.
ICR has always been my dream institution to work at, given its global reputation for cutting-edge cancer research. With access to world-class resources and an environment that fosters innovation, it has been an incredible learning experience. I’m eager to bring back the knowledge and techniques I’ve gained to contribute to cancer research in Pakistan.
What are some of the challenges you’ve faced in cancer research, and how have you navigated them?
Cancer research is incredibly complex and comes with many challenges—one being the adaptability of cancer cells, which develop resistance to treatments. Additionally, the signalling pathways involved are intricate, making it difficult to target cancer effectively. To overcome these challenges, interdisciplinary collaboration is essential. Combining chemistry, biology, and computational modelling has allowed us to tackle these problems from multiple angles. And, of course, failure is a part of the process. It’s important to remain resilient, constantly refine your approach, and view setbacks as valuable learning opportunities.
Can you share an accomplishment in your research that you’re particularly proud of?
One of my proudest moments was working on a bacterial inhibition project with Dr. Ghayoor Abbass and Dr. Shaper Mirza, Associate Professors at SBASSE. We were targeting E. coli, which causes urinary tract infections, and I unexpectedly discovered a new functional group in a compound that inhibited the bacteria. This discovery was both unexpected and highly significant, as it provided new insights into potential antibacterial agents for highly resistant bacteria. This breakthrough is being prepared for publication, and it has truly validated the importance of my work. It reminded me of the profound impact scientific research can have in addressing real-world health challenges.
How did your time at LUMS prepare you for your research at ICR?
LUMS provided a rigorous academic foundation and solid research training. The confidence, skills, and critical thinking I developed at LUMS have been invaluable in navigating the challenges of cutting-edge cancer research. The laboratory techniques and methodologies I was trained with at the Cancer Therapeutics Lab (CTL) in LUMS were on par with international standards, allowing me to transition smoothly into this new research setting.
What are your long-term goals in cancer research, and how do you hope to contribute to the field moving forward?
My ultimate goal is to continue pushing the boundaries of cancer research, focusing on discovering new compounds that can improve treatment options. Once I return to Pakistan, I plan to integrate the advanced methodologies and techniques I’ve gained from my experience abroad into local research. There is enormous potential for growth in Pakistan’s cancer research field, and I believe that with greater collaboration and innovation, we can make meaningful strides in advancing cancer treatment. Beyond research, I hope to raise awareness and help improve the cancer research infrastructure in Pakistan, so we can offer better treatment options for those affected by the disease.
What advice would you give to students at LUMS who are passionate about pursuing research?
My advice would be to stay persistent and build a strong foundation in your field. Research is rarely a smooth journey, and setbacks are inevitable. However, it’s important to view these challenges as opportunities to grow and refine your approach. Critical thinking, resilience, and an unwavering belief in yourself are key to overcoming obstacles. Never doubt your potential—you can achieve great things, and you are just as capable as anyone else in the world!
